Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

Hepatocytes form a crucially important cell layer that separates sinusoidal blood from the
canalicular bile. They have a uniquely organized polarity with a basal membrane facing liver …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

The polarized distribution of functions in polarized cells requires the coordinated interaction
of three machineries that modify the basic mechanisms of intracellular protein trafficking and …

Summary Sec1/Munc18 (SM) proteins are required for every step of intracellular membrane
fusion, but their molecular mechanism of action has been unclear. In this work, we …

In the early days of epithelial cell biology, researchers working with kidney and/or intestinal
epithelial cell lines and with hepatocytes described the biosynthetic and recycling routes …

As polarized cells, neurons maintain different sets of resident plasma membrane proteins in
their axons and dendrites, which is consistent with the different roles that these neurites …

Major advances in understanding regulated mucin secretion from airway goblet cells have
been made in the past decade in the areas of pharmacology and basic cell biology. For …

Microvillus inclusion disease (MVID) is a disorder of intestinal epithelial differentiation
characterized by life-threatening intractable diarrhea. MVID can be diagnosed based on loss …

In the central nervous system, a multilayered membrane layer known as the myelin sheath
enwraps axons, and is required for optimal saltatory signal conductance. The sheath …