Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Pathophysiology of Post-COVID syndromes: a new perspective

GES Batiha, HM Al-Kuraishy, AI Al-Gareeb, NN Welson - Virology Journal, 2022 - Springer
Most COVID-19 patients recovered with low mortality; however, some patients experienced
long-term symptoms described as “long-COVID” or “Post-COVID syndrome”(PCS). Patients …

Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

[HTML][HTML] Mast cell activation symptoms are prevalent in Long-COVID

LB Weinstock, JB Brook, AS Walters, A Goris… - International Journal of …, 2021 - Elsevier
Objectives Hyper-inflammation caused by COVID-19 may be mediated by mast cell
activation (MCA) which has also been hypothesized to cause Long-COVID (LC) symptoms …

A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection

DA Jamison Jr, S Anand Narayanan… - European Journal of …, 2022 - nature.com
COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives
and 257 million cases reported globally. This virus and disease have significantly affected …

The pathophysiology of long COVID throughout the renin-angiotensin system

S Khazaal, J Harb, M Rima, C Annweiler, Y Wu, Z Cao… - Molecules, 2022 - mdpi.com
COVID-19 has expanded across the world since its discovery in Wuhan (China) and has
had a significant impact on people's lives and health. Long COVID is a term coined by the …

[HTML][HTML] SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

U Tripathi, R Nchioua, LGPL Prata, Y Zhu… - Aging (albany …, 2021 - ncbi.nlm.nih.gov
Senescent cells, which arise due to damage-associated signals, are apoptosis-resistant and
can express a pro-inflammatory, tissue-destructive senescence-associated secretory …

An overview of recent insights into the response of TLR to SARS-CoV-2 infection and the potential of TLR agonists as SARS-CoV-2 vaccine adjuvants

MEH Kayesh, M Kohara, K Tsukiyama-Kohara - Viruses, 2021 - mdpi.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led
to coronavirus disease (COVID-19), a global health pandemic causing millions of deaths …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

Oral famotidine versus placebo in non-hospitalised patients with COVID-19: a randomised, double-blind, data-intense, phase 2 clinical trial

CM Brennan, S Nadella, X Zhao, RJ Dima… - Gut, 2022 - gut.bmj.com
Objective We assessed whether famotidine improved inflammation and symptomatic
recovery in outpatients with mild to moderate COVID-19. Design Randomised, double-blind …