The past decade has brought many advances in our understanding of GABA A receptor-
mediated ethanol action in the central nervous system. We now know that specific GABA A …

Alcoholism is a common, heritable, chronic relapsing disorder. GABAA receptors undergo
allosteric modulation by ethanol, anesthetics, benzodiazepines and neurosteroids and have …

ABSTRACT A challenging question that continues unanswered in the field of addiction is
why some individuals are more vulnerable to substance use disorders than others …

Epidemiological studies provided a large body of evidence that personality dimensions are
influenced by genetic factors and that the genetic component is highly complex, polygenic …

▪ Abstract Even the most extreme environmentalists along the nature-nurture continuum in
psychology now acknowledge that genes often contribute to individual differences in …

Twin studies have established that there are substantial genetic influences on alcoholism
(0.5-0.6) in both men and women. Our knowledge of behaviors predisposing to alcoholism …

FAMILY, TWIN, AND adoption studies have convincingly demonstrated that genes play an
important role in the development of alcohol dependence, accounting for approximately 50 …

Context Alcohol facilitates γ-aminobutyric acid (GABA) function, and GABA type A (GABA A)
receptor–facilitating agents suppress alcohol withdrawal symptoms. Advances in molecular …

The field of genetics holds great promise for furthering our understanding of the etiology of
drug dependence and for identifying novel targets for treatment. Genetic studies utilizing …

This article presents the proceedings of a symposium held at the meeting of the International
Society for Biomedical Research on Alcoholism (ISBRA) in Mannheim, Germany, in October …