Utility of Physiologically Based Pharmacokinetic Modeling in Predicting and Characterizing Clinical Drug Interactions
RS Foti - Drug Metabolism and Disposition, 2024 - Elsevier
Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic dynamic
modeling approach that can be used to predict or retrospectively describe changes in drug …
modeling approach that can be used to predict or retrospectively describe changes in drug …
Physiological Dynamics in the Upper Gastrointestinal Tract and the Development of Gastrointestinal Absorption Models for the Immediate-Release Oral Dosage Forms …
K Wang, GL Amidon, DE Smith - Pharmaceutical Research, 2023 - Springer
This review is a revisit of various oral drug absorption models developed in the past
decades, focusing on how to incorporate the physiological dynamics in the upper …
decades, focusing on how to incorporate the physiological dynamics in the upper …
[HTML][HTML] Advancements in Virtual Bioequivalence: A Systematic Review of Computational Methods and Regulatory Perspectives in the Pharmaceutical Industry
N Alotaiq, D Dermawan - Pharmaceutics, 2024 - mdpi.com
Background/Objectives: The rise of virtual bioequivalence studies has transformed the
pharmaceutical landscape, enabling more efficient drug development processes. This …
pharmaceutical landscape, enabling more efficient drug development processes. This …
An extension of biorelevant fed-state dissolution tests to clinical pharmacokinetics–A study on gastrointestinal factors influencing rivaroxaban exposure and efficacy in …
M Romański, J Giebułtowicz, E Gniazdowska… - International Journal of …, 2024 - Elsevier
A direct oral anticoagulant rivaroxaban fails to prevent stroke and systemic embolism in one-
to-several percent of patients with nonvalvular atrial fibrillation (NVAF), but the reasons are …
to-several percent of patients with nonvalvular atrial fibrillation (NVAF), but the reasons are …
Modeling and Simulations in Latin-American Generic Markets: Perspectives from Chilean Local Industry, Regulatory Agency, and Academia
MA García, C Paulos, M Ibarra Viñales… - Molecular …, 2024 - ACS Publications
In the last 20 years, modeling and simulations (M&S) have gained increased attention in
pharmaceutical sciences. International industry and world-reference agencies have used …
pharmaceutical sciences. International industry and world-reference agencies have used …
A quantification of gastric and duodenal fluid volumes in older adults using MRI
C Demeester, M Van der Veken, J Brouwers… - International Journal of …, 2024 - Elsevier
Older adults are an inherently heterogeneous population with various underlying
pathologies, medication use, and habits. In this study, the variability of this population was …
pathologies, medication use, and habits. In this study, the variability of this population was …
[HTML][HTML] Analyzing parametric influences driving age-associated changes in absorption using a PBPK-GSA approach
D Robins, A Lehmann, K Krollik, M Vertzoni - European Journal of …, 2024 - Elsevier
The advanced age population may be susceptible to an increased risk of adverse effects
due to increased drug exposure after oral dosing. Factors such as high-interindividual …
due to increased drug exposure after oral dosing. Factors such as high-interindividual …
The ADME Characteristics of siRNA Therapeutics and the Opportunity to Predict Disposition in Pregnant Women
O Amaeze, N Isoherranen, S Shum - Drug Metabolism and Disposition, 2024 - Elsevier
Small interfering RNA (siRNA) therapeutics represent an emerging class of
pharmacotherapy with the potential to address previously hard-to-treat diseases. Currently …
pharmacotherapy with the potential to address previously hard-to-treat diseases. Currently …
In‐Depth Analysis of the Selection of PBPK Modeling Tools: Bibliometric and Social Network Analysis of the Open Systems Pharmacology Community
A Dallmann, D Teutonico, S Schaller… - The Journal of …, 2024 - Wiley Online Library
Abstract Since the Open Source Initiative laid the foundation for the open source software
environment in 1998, the popularity of free and open source software has been steadily …
environment in 1998, the popularity of free and open source software has been steadily …
Mathematical Modeling of the Gastrointestinal System for Preliminary Drug Absorption Assessment
The objective of this study is to demonstrate the potential of a multicompartmental
mathematical model to simulate the activity of the gastrointestinal system after the intake of …
mathematical model to simulate the activity of the gastrointestinal system after the intake of …