Cyclic olefin polymers (COPs) are increasingly popular as substrate material for
microfluidics. This is due to their promising properties, such as high chemical resistance, low …

The area of micro total analysis systems (μTAS), also called “lab on a chip” or miniaturized
analysis systems, is growing rapidly. This paper represents an update of the earlier reviews …

Introduction: The development of emerging in vitro tissue culture platforms can be useful for
predicting human response to new compounds, which has been traditionally challenging in …

Significant progress in the development of miniaturized microfluidic systems has occurred
since their inception over a decade ago. This is primarily due to the numerous advantages of …

The microfluidic lab-on-a-chip allows scientists to conduct chemical and biochemical
analysis in a miniaturized format so small that properties and effects are successfully …

ABSTRACT The cytochrome P450 (P450) field came out of interest in the metabolism of
drugs, carcinogens, and steroids, which remain major focal points. Over the years we have …

Here we describe a liquid chromatography/mass spectrometry (LC/MS) method with
automated online extraction (LC/LC/MS) to simultaneously determine the in vitro inhibitory …

Microfluidic technologies enable the fabrication of advanced in vitro systems incorporating
liver tissue or cells to perform metabolism and toxicity studies for drugs and other …

Metabolomics is an emerging area of research focused on measuring small molecules in
biological samples. There are a number of different types of metabolomics, ranging from …

In this work, we developed a microfluidic device for the imitation of drug metabolism in
human liver and its cytotoxicity on cells. The integrated microfluidic device consists of three …