Molecular targeted therapies in glioblastoma multiforme: a systematic overview of global trends and findings
This systematic review assesses current molecular targeted therapies for glioblastoma
multiforme (GBM), a challenging condition with limited treatment options. Using PRISMA …
multiforme (GBM), a challenging condition with limited treatment options. Using PRISMA …
Death‐associated protein kinase (DAPK) family modulators: current and future therapeutic outcomes
AK Farag, EJ Roh - Medicinal Research Reviews, 2019 - Wiley Online Library
Serine/threonine kinases (STKs) represent the majority of discovered kinases to date even
though a few Food and Drug Administration approved STKs inhibitors are reported. The third …
though a few Food and Drug Administration approved STKs inhibitors are reported. The third …
Structure-based design of pyridone–aminal eFT508 targeting dysregulated translation by selective mitogen-activated protein kinase interacting kinases 1 and 2 …
SH Reich, PA Sprengeler, GG Chiang… - Journal of medicinal …, 2018 - ACS Publications
Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated
protein kinase interacting kinases (MNK) 1/2 are key regulators of mRNA translation …
protein kinase interacting kinases (MNK) 1/2 are key regulators of mRNA translation …
Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-β1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with …
Head and neck squamous cell carcinoma (HNSCC) is an extremely aggressive cancer with
a poor prognosis and low patient survival. Because chemotherapy for advanced HNSCC is …
a poor prognosis and low patient survival. Because chemotherapy for advanced HNSCC is …
Degradation of DRAK1 by CUL3/SPOP E3 Ubiquitin ligase promotes tumor growth of paclitaxel-resistant cervical cancer cells
Despite favorable responses to initial chemotherapy, drug resistance is a major cause
limiting chemotherapeutic efficacy in many advanced cancers. However, mechanisms that …
limiting chemotherapeutic efficacy in many advanced cancers. However, mechanisms that …
Targeting death-associated protein kinases for treatment of human diseases: recent advances and future directions
L Zhang, B Luo, Y Lu, Y Chen - Journal of Medicinal Chemistry, 2023 - ACS Publications
The death-associated protein kinase (DAPK) family is a member of the calcium/calmodulin-
regulated serine/threonine protein kinase family, and studies have shown that its role, as its …
regulated serine/threonine protein kinase family, and studies have shown that its role, as its …
[HTML][HTML] A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway
SB Yoon, H Hong, HJ Lim, JH Choi, YP Choi… - … Pharmaceutica Sinica B, 2023 - Elsevier
Abstract Interleukin-1 receptor-associated kinase 4 (IRAK4) is a pivotal enzyme in the Toll-
like receptor (TLR)/MYD88 dependent signaling pathway, which is highly activated in …
like receptor (TLR)/MYD88 dependent signaling pathway, which is highly activated in …
Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of
XPO1 inhibitors, selinexor and eltanexor, in high-risk myelodysplastic neoplasms (MDS) …
XPO1 inhibitors, selinexor and eltanexor, in high-risk myelodysplastic neoplasms (MDS) …
Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles
CG Kurz, F Preuss, A Tjaden, M Cusack… - Journal of Medicinal …, 2022 - ACS Publications
Serine/threonine kinase 17A (death-associated protein kinase-related apoptosis-inducing
protein kinase 1─ DRAK1) is a part of the death-associated protein kinase (DAPK) family …
protein kinase 1─ DRAK1) is a part of the death-associated protein kinase (DAPK) family …
Inhibition of miR-182-5p attenuates ROS and protects against myocardial ischemia-reperfusion injury by targeting STK17A
X Li, Y Jin - Cell Cycle, 2022 - Taylor & Francis
Reperfusion therapy for acute myocardial infarction inevitably leads to ischemia-reperfusion
(I/R) injury. A number of miRNAs are reported to be involved in I/R injury. This study aims to …
(I/R) injury. A number of miRNAs are reported to be involved in I/R injury. This study aims to …