[HTML][HTML] An overview on the synthesis of lamellarins and related compounds with biological interest

VPM Mitsiou, AMN Antonaki, MD Douka, KE Litinas - Molecules, 2024 - mdpi.com
Lamellarins are natural products with a [3, 4]-fused pyrrolocoumarin skeleton possessing
interesting biological properties. More than 70 members have been isolated from diverse …

Diversely functionalized isoquinolines and their core-embedded heterocyclic frameworks: a privileged scaffold for medicinal chemistry

A Vijayakumar, M Manod, RB Krishna… - RSC Medicinal …, 2023 - pubs.rsc.org
Isoquinoline-enrooted organic small-molecules represent a challenging molecular target in
the organic synthesis arsenal attributed of its structural diversity and therapeutic importance …

Synthesis of Pyrrolo[2,1-a]isoquinolines through Cu-Catalyzed Condensation/Addition/Oxidation/Cyclization Cascade

HL Cui, XH Chen - The Journal of Organic Chemistry, 2022 - ACS Publications
We have developed a copper-catalyzed synthesis of pyrrolo [2, 1-a] isoquinolines with
terminal alkynes, aldehydes, and tetrahydroisoquinolines. A variety of pyrrolo [2, 1-a] …

Recent Advances on the Synthesis of Chromenone Fused Pyrrolo [2, 1-a] isoquinoline Derivatives

S Bera, A Maji, S Patra, DS Mahanty… - New Journal of …, 2023 - pubs.rsc.org
Both chromenone and pyrrolo [2, 1-a] isoquinolines (containing ring-junction nitrogen) are
privileged scaffolds in the field of synthetic as well as medicinal chemistry. These fused …

A two-step approach to a hexacyclic lamellarin core via 1, 3-dipolar cycloaddition of isoquinolinium ylides to nitrostilbenes

EA Silyanova, AV Samet… - The Journal of Organic …, 2022 - ACS Publications
A Two-Step Approach to a Hexacyclic Lamellarin Core via 1,3-Dipolar Cycloaddition of
Isoquinolinium Ylides to Nitrostilbenes | The Journal of Organic Chemistry Recently Viewed …

Iron-Catalyzed Synthesis of Pyrrolo [2, 1-a] isoquinolines via 1, 3-Dipolar Cycloaddition/Elimination/Aromatization Cascade and Modifications

XH Chen, YY Pan, WX Wang, HL Cui - Synlett, 2022 - thieme-connect.com
We have developed an iron-catalyzed synthesis of pyrrolo [2, 1-a] isoquinoline derivatives
with tetrahydroisoquinolines, arylacyl bromides, and nitroolefins. Highly functionalized …

Construction of Polyheterocyclic Compounds by Lewis Acid Mediated Intramolecular [3+ 2] Cycloaddition Reaction

P Dahiya, A Yadav, R Budhwan… - European Journal of …, 2023 - Wiley Online Library
An efficient domino approach has been developed for the synthesis of polyheterocyclic
derivatives constituting pyrrole moiety. Lewis acid catalyzed reaction of 2‐substituted‐2 …

Polyalkoxy-substituted nitrostilbenes in the synthesis of lamellarin analogs. Formal synthesis of lamellarin H

EA Silyanova, AS Maksimenko, MD Brunner… - Russian Chemical …, 2023 - Springer
Lamellarin D trimethyl ether was prepared by 1, 3-dipolar cycloaddition of 6, 7-
dimethoxyisoquinolinium ylide to pentamethoxy-substituted nitrostilbene followed by a …

Three-component synthesis of 5, 6-dihydropyrrolo [2, 1-a] isoquinolines from 1-aroyl-3, 4-dihydroisoquinolines, electron-deficient alkynes and NH-acids

AR Miftyakhova, MB Sidakov, TN Borisova… - Tetrahedron …, 2022 - Elsevier
The three-component domino reaction involving 1-aroyl-3, 4-dihydroisoquinolines, terminal
alkynes, and cyclic NH-acids is a new method for the synthesis of 5, 6-dihydropyrrolo [2, 1-a] …

Base-Mediated Cascade Lactonization/1,3-Dipolar Cycloaddition Pathway for the One-Pot Assembly of Coumarin-Functionalized Pyrrolo[2,1-a]isoquinolines

Q Tang, Y Liu, BB Fei, Q Tao, C Wang… - The Journal of …, 2024 - ACS Publications
An elegant and highly concise strategy for the construction of coumarin-functionalized
pyrrolo [2, 1-a] isoquinolines from available propargylamines and isoquinolinium N-ylides …