Fucoidans are a class of sulfated fucose-rich polysaccharides found in brown marine algae
and echinoderms. Fucoidans have an attractive array of bioactivities and potential …

Rapid advances in the cancer stem cell (CSC) field have provided cause for optimism for the
development of more reliable cancer therapies in the future. Strategies aimed at efficient …

Pancreatic adenocarcinoma is currently the fourth leading cause for cancer-related mortality.
Stem cells have been implicated in pancreatic tumor growth, but the specific role of these …

Nanomedicines achieve tumor-targeted delivery mainly through enhanced permeability and
retention (EPR) effect following intravenous (IV) administration. Unfortunately, the EPR effect …

Genetically engineered mouse models (GEMMs) have dramatically improved our
understanding of tumor evolution and therapeutic resistance. However, sequential genetic …

BACKGROUND & AIMS: Early metastasis is a hallmark of pancreatic ductal
adenocarcinoma and responsible for> 90% of pancreatic cancer death. Because little is …

Hypoxia and hypoxia-inducible factor-1 (HIF-1) play a critical role in glioblastoma multiforme
(GBMs). CXCR4 is involved in angiogenesis and is upregulated by HIF-1α. CXCR4 is a …

The tumor microenvironment is extremely complex that depends on tumor cell interaction
with the responding host cells. Angiogenesis, or new blood vessel growth from preexisting …

Chemokine networks regulate a variety of cellular, physiological, and immune processes.
These normal functions can become appropriated by cancer cells to facilitate a more …

Background: Pancreatic cancer cells are highly resistant to drug therapy; however,
underlying causes remain largely unknown. We hypothesised that the activation of CXCL12 …