Vaccine adjuvants: mechanisms and platforms

T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …

New-age vaccine adjuvants, their development, and future perspective

SK Verma, P Mahajan, NK Singh, A Gupta… - Frontiers in …, 2023 - frontiersin.org
In the present scenario, immunization is of utmost importance as it keeps us safe and
protects us from infectious agents. Despite the great success in the field of vaccinology …

[HTML][HTML] Inflammation-mediated tissue damage in pulmonary tuberculosis and host-directed therapeutic strategies

D Tiwari, AR Martineau - Seminars in Immunology, 2023 - Elsevier
Abstract Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …

Therapeutic vaccines for tuberculosis: an overview

R Bouzeyen, B Javid - Frontiers in Immunology, 2022 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis is the world's deadliest bacterial
infection, resulting in more than 1.4 million deaths annually. The emergence of drug …

Next-generation TB vaccines: progress, challenges, and prospects

L Zhuang, Z Ye, L Li, L Yang, W Gong - Vaccines, 2023 - mdpi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a prevalent global
infectious disease and a leading cause of mortality worldwide. Currently, the only available …

Key advances in vaccine development for tuberculosis—Success and challenges

R Lai, AF Ogunsola, T Rakib, SM Behar - NPJ vaccines, 2023 - nature.com
Breakthrough findings in the clinical and preclinical development of tuberculosis (TB)
vaccines have galvanized the field and suggest, for the first time since the development of …

Selective COX-2 inhibitors: road from success to controversy and the quest for repurposing

AA El-Malah, MM Gineinah, PK Deb, AN Khayyat… - Pharmaceuticals, 2022 - mdpi.com
The introduction of selective COX-2 inhibitors (so-called 'coxibs') has demonstrated
tremendous commercial success due to their claimed lower potential of serious …

Vaccine development against tuberculosis before and after Covid-19

SHE Kaufmann - Frontiers in Immunology, 2023 - frontiersin.org
Coronavirus disease (Covid-19) has not only shaped awareness of the impact of infectious
diseases on global health. It has also provided instructive lessons for better prevention …

Potential repurposed drug candidates for tuberculosis treatment: progress and update of drugs identified in over a decade

K Sharma, F Ahmed, T Sharma, A Grover… - ACS …, 2023 - ACS Publications
The devastating impact of Tuberculosis (TB) has been a menace to mankind for decades.
The World Health Organization (WHO) End TB Strategy aims to reduce TB mortality up to …

It Takes a Village: The Multifaceted Immune Response to Mycobacterium tuberculosis Infection and Vaccine-Induced Immunity

SE Larsen, BD Williams, M Rais, RN Coler… - Frontiers in …, 2022 - frontiersin.org
Despite co-evolving with humans for centuries and being intensely studied for decades, the
immune correlates of protection against Mycobacterium tuberculosis (Mtb) have yet to be …