The immobility of plants exerted evolutionary selection pressures resulting in the production
of thousands of chemical substances thought to function as pesticides against predation by …

Abstract In 2015, the Expert Panel of the Flavor and Extract Manufacturers Association
(FEMA) initiated a re-evaluation of the safety of over 250 natural flavor complexes (NFCs) …

The terms “significant” and “p-value” are important for biomedical researchers and readers
of biomedical papers including pharmacologists. No other statistical result is misinterpreted …

In 1990, Ames and Gold described a conundrum of “too many carcinogens” among
chemicals tested in rodent bioassays. Their proposed nongenotoxic carcinogenic …

Industrial chemicals, pharmaceuticals along with illicit drugs (IDs), as well as day-to-day
personal care products (PCPs) are documented as contaminants of emerging concerns …

Medical Product Safety Evaluation: Biological Models and Statistical Methods presents
cutting-edge biological models and statistical methods that are tailored to specific objectives …

Figure 1.1 The sequence of events between initial exposure to a toxicant and final disease
outcome; note that genetic susceptibility influences every level of toxicological analysis. The …

Two-year toxicology and carcinogenesis rodent studies conducted at the National
Toxicology Program (NTP) are used to identify potential adverse health effects in humans …

Abstract β-Myrcene is a flavoring substance that occurs naturally in a large variety of foods.
At the request of the European Food Safety Authority (EFSA) for additional toxicological data …

Abstract Based on the World Health Organization, cancer is the second leading cause of
death globally and is responsible for an estimated 9.6 million deaths in 2018. Globally …