Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …

Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is
essential for cell division and can inhibit cell death. Normally it is only expressed in actively …

Cell-to-cell communication across multiple cell types and tissues strictly governs proper
functioning of metazoans and extensively relies on interactions between secreted ligands …

Regulated transcription controls the diversity, developmental pathways and spatial
organization of the hundreds of cell types that make up a mammal. Using single-molecule …

With the advancement of next-generation sequencing and mass spectrometry, there is a
growing need for the ability to merge biological features in order to study a system as a …

Housekeeping genes are involved in basic cell maintenance and, therefore, are expected to
maintain constant expression levels in all cells and conditions. Identification of these genes …

Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved
in inhibition of apoptosis and regulation of cell cycle. These functional attributes make …

We describe a technology, the NanoString nCounter gene expression system, which
captures and counts individual mRNA transcripts. Advantages over existing platforms …

Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …

The parts of the genome transcribed by a cell or tissue reflect the biological processes and
functions it carries out. We characterized the features of mammalian tissue transcriptomes at …