RNA in cancer

GJ Goodall, VO Wickramasinghe - Nature Reviews Cancer, 2021 - nature.com
While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

Best practice standards for circular RNA research

AF Nielsen, A Bindereif, I Bozzoni, M Hanan… - Nature …, 2022 - nature.com
Circular RNAs (circRNAs) are formed in all domains of life and via different mechanisms.
There has been an explosion in the number of circRNA papers in recent years; however, as …

Mechanisms and functions of long non-coding RNAs at multiple regulatory levels

X Zhang, W Wang, W Zhu, J Dong, Y Cheng… - International journal of …, 2019 - mdpi.com
Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily
interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression …

MicroRNAs as therapeutic targets in cardiovascular disease

B Laggerbauer, S Engelhardt - The Journal of clinical …, 2022 - Am Soc Clin Investig
The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …

Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

Overview of microRNA biogenesis, mechanisms of actions, and circulation

J O'Brien, H Hayder, Y Zayed, C Peng - Frontiers in endocrinology, 2018 - frontiersin.org
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating
gene expression. The majority of miRNAs are transcribed from DNA sequences into primary …

The biochemical basis of microRNA targeting efficacy

SE McGeary, KS Lin, CY Shi, TM Pham, N Bisaria… - Science, 2019 - science.org
INTRODUCTION MicroRNAs (miRNAs) are short RNAs that guide repression of mRNA
targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in …

[HTML][HTML] Metazoan micrornas

DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

Noncoding RNA: RNA regulatory networks in cancer

JJ Chan, Y Tay - International journal of molecular sciences, 2018 - mdpi.com
Noncoding RNAs (ncRNAs) constitute the majority of the human transcribed genome. This
largest class of RNA transcripts plays diverse roles in a multitude of cellular processes, and …

The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer

J Xu, J Xu, X Liu, J Jiang - Cell death discovery, 2022 - nature.com
Abstract Non-coding RNAs (ncRNAs), which occupy the vast majority of human transcripts
are known for their inability to encode proteins. NcRNAs consist of a diverse range of RNA …