Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Cancer arises as a consequence of cumulative disruptions to cellular growth control with
Darwinian selection for those heritable changes that provide the greatest clonal advantage …

Abstract Programmed death receptor-1 (PD-1) blockade have achieved some efficacy but
only in a fraction of patients with hepatocellular carcinoma (HCC). Programmed cell death 1 …

PRDM9 is a zinc finger protein that binds DNA at specific locations in the genome where it
trimethylates histone H3 at lysines 4 and 36 at surrounding nucleosomes. During meiosis in …

During meiosis, maternal and paternal chromosomes undergo exchanges by homologous
recombination. This is essential for fertility and contributes to genome evolution. In many …

Hyperdiploidy is the largest genetic entity B-cell precursor acute lymphoblastic leukemia in
children. The diagnostic hallmark of its two variants that will be discussed in detail herein is …

In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent
childhood hematological malignancy, as well as the leading cause of childhood cancer …

PRDM9 (PR domain-containing protein 9) is a meiosis-specific protein that trimethylates
H3K4 and controls the activation of recombination hot spots. It is an essential enzyme in the …

The PR/SET domain family (PRDM) comprise a family of genes whose protein products
share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) …

The PRDM family of proteins share a unique structure, with an N-terminal PR domain, which
has a potential methyltransferase activity, followed by a distinct number of zinc fingers at the …