Simulation and sensitivity analysis on the parameter of non-targeted irradiation effects model

MH Nasir, FM Siam - Jurnal Teknologi, 2019 - journals.utm.my
Real-life situations showed damage effects on non-targeted cells located in the vicinity of an
irradiation region, due to danger signal molecules released by the targeted cells. This effect …

Effect of Gold Nanoparticle Radiosensitization on DNA Damage Using a Quartz Tuning Fork Sensor

N Alanazi, R Alanazi, M Algawati, K Alzahrani… - Micromachines, 2023 - mdpi.com
The development of sensor technology enables the creation of DNA-based biosensors for
biomedical applications. Herein, a quartz tuning fork (QTF) sensing system was employed …

Parameter estimation for a mechanistic model of high dose irradiation damage using Nelder-Mead Simplex Method and Genetic Algorithm

FM Siam, MHA Kamal, F Johar - Jurnal Teknologi, 2016 - journals.utm.my
Radiation therapy is one of the cancer cells treatments that use high-energy radiation to
shrink tumors and kill cancer cells. Radiation therapy kills cancer cells by damaging their …

Elucidating the Effects of Ionizing Radiation on Immune Cell Populations: A Mathematical Modeling Approach with Special Emphasis on Fractional Derivatives

DY Alzahrani, FM Siam, FA Abdullah - Mathematics, 2023 - mdpi.com
Despite recent advances in the mathematical modeling of biological processes and real-
world situations raised in the day-to-day life phase, some phenomena such as immune cell …

Mathematical modeling in radiation oncology: Translating mathematical models into the clinic

RC Rockne, P Frankel - Advances in Radiation Oncology, 2017 - Springer
The goal of precision medicine is to tailor treatments to the individual patient's disease. In
radiation oncology, this means tailoring the dose to the boundaries of the tumor, but also to …

Mechanistic model of radiation-induced bystander effects to cells using structured population approach

FM Siam, MH Nasir - Matematika, 2018 - matematika.utm.my
In irradiation process, instead of traverse on the targeted cells, there is side effect happens
to non-targeted cells. The targeted cells that had been irradiated with ionizing radiation …

[PDF][PDF] Mini-review: recent updates on the mathematical modelling of radiation-induced bystander effects

MH Nasir, FM Siam - Malaysian Journal of Fundamental and …, 2017 - researchgate.net
Radiotherapy treatment uses ionizing radiation (IR) in order to kill cancer cells. However, the
IR exerted its effects outside the radiation field and causes cell death in healthy cells. This …

Mathematical Models of the Generation of Radiation-induced DNA Double-strand Breaks and Misrepair Cells by Direct and Indirect Action

H Rashid, FM Siam, N Maan… - Malaysian Journal of …, 2022 - mjfas.utm.my
Free radical carries an unpaired electron in the outer shell which is very reactive and
becomes toxic to DNA. The direct action hits cell directly, while indirect action is the …

[PDF][PDF] Ionizing Irradiation Effects Modelling in Cells Population with Gold Nanoparticles

H Rashid, FM Siam, N Maan… - Malays. J. Fundam. Appl …, 2021 - academia.edu
Radiosensitizer such as gold nanoparticle is a promising agent to be used in radiotherapy to
increase the number of cancer cell death. Gold nanoparticle increases the production of the …

Parameter estimation of HFMD infection in Malaysia with SIR model

H Nasir, FM Siam - Annals of Mathematical Modeling, 2023 - a-mm.org
Hand, foot and mouth disease (HFMD) is a mildly infectious disease that happens to
children due to low body immunity against viruses. In this paper, a simple SIR model is …