ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies
AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
Association of apolipoprotein E genotypes with lipid levels and coronary risk
AM Bennet, E Di Angelantonio, Z Ye, F Wensley… - Jama, 2007 - jamanetwork.com
ContextPrevious reviews of associations of apolipoprotein E (apoE) genotype and coronary
disease have been dominated by smaller studies that are liable to biases. ObjectiveTo …
disease have been dominated by smaller studies that are liable to biases. ObjectiveTo …
Cholesterol: its regulation and role in central nervous system disorders
M Orth, S Bellosta - Cholesterol, 2012 - Wiley Online Library
Cholesterol is a major constituent of the human brain, and the brain is the most cholesterol‐
rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain …
rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain …
Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease
Background: Apolipoprotein E (apoE) genotypes play critical roles in lipid metabolism and
are believed to influence risk for coronary heart disease (CHD). Despite many population …
are believed to influence risk for coronary heart disease (CHD). Despite many population …
APOE distribution in world populations with new data from India and the UK
Background: The APOE gene and its protein product is associated with a number of plasma
proteins like very-low density lipoprotein (VLDL), high density lipoprotein (HDL) …
proteins like very-low density lipoprotein (VLDL), high density lipoprotein (HDL) …
Role of apolipoprotein E in neurodegenerative diseases
Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons
in the central nervous system. APOE-dependent alterations of the endocytic pathway can …
in the central nervous system. APOE-dependent alterations of the endocytic pathway can …
Lipoproteins in the central nervous system: from biology to pathobiology
AC Raulin, YA Martens, G Bu - Annual review of biochemistry, 2022 - annualreviews.org
The brain, as one of the most lipid-rich organs, heavily relies on lipid transport and
distribution to maintain homeostasis and neuronal function. Lipid transport mediated by …
distribution to maintain homeostasis and neuronal function. Lipid transport mediated by …
The key role of apolipoprotein E in atherosclerosis
K Greenow, NJ Pearce, DP Ramji - Journal of molecular medicine, 2005 - Springer
Apolipoprotein E is a multifunctional protein that is synthesized by the liver and several
peripheral tissues and cell types, including macrophages. The protein is involved in the …
peripheral tissues and cell types, including macrophages. The protein is involved in the …
Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis
DH McDermott, JPJ Halcox, WH Schenke… - Circulation …, 2001 - Am Heart Assoc
Fractalkine, a chemokine expressed by inflamed endothelium, induces leukocyte adhesion
and migration via the receptor CX3CR1, and the CX3CR1 polymorphism V249I affects …
and migration via the receptor CX3CR1, and the CX3CR1 polymorphism V249I affects …
HDL proteome and Alzheimer's disease: evidence of a link
Several lines of epidemiological evidence link increased levels of high-density lipoprotein-
cholesterol (HDL-C) with lower risk of Alzheimer's disease (AD). This observed relationship …
cholesterol (HDL-C) with lower risk of Alzheimer's disease (AD). This observed relationship …