Structural biology of shelterin and telomeric chromatin: the pieces and an unfinished puzzle
H Hu, HL Yan, THD Nguyen - Biochemical Society Transactions, 2024 - portlandpress.com
The six-subunit shelterin complex binds to mammalian telomeres and protects them from
triggering multiple DNA damage response pathways. The loss of this protective function by …
triggering multiple DNA damage response pathways. The loss of this protective function by …
Structural Motifs at the Telomeres and Their Role in Regulatory Pathways
AFR Alanazi, GN Parkinson, S Haider - Biochemistry, 2024 - ACS Publications
Telomeres are specialized structures, found at the ends of linear chromosomes in eukaryotic
cells, that play a crucial role in maintaining the stability and integrity of genomes. They are …
cells, that play a crucial role in maintaining the stability and integrity of genomes. They are …
The shelterin component TRF2 mediates columnar stacking of human telomeric chromatin
Telomere repeat binding factor 2 (TRF2) is an essential component of the telomeres and
also plays an important role in a number of other non-telomeric processes. Detailed …
also plays an important role in a number of other non-telomeric processes. Detailed …
TRF1 and TRF2: pioneering targets in telomere-based cancer therapy
A Kallingal, R Krzemieniecki, N Maciejewska… - Journal of Cancer …, 2024 - Springer
This article presents an in-depth exploration of the roles of Telomere Repeat-binding Factors
1 and 2 (TRF1 and TRF2), and the shelterin complex, in the context of cancer biology. It …
1 and 2 (TRF1 and TRF2), and the shelterin complex, in the context of cancer biology. It …
Interactions of Polydopamine Nanoparticles with Serine and Cysteine Proteases: Implications for Enhancing Protein Stabilization and Enzyme Activity
D Chahar, B Yadav, P Venkatesu - ACS Applied Nano Materials, 2024 - ACS Publications
The interactions between polydopamine nanoparticles (PDA NPs) with serine protease α-
chymotrypsin (α-CT) and cysteine protease stem bromelain (SB) have prompted significant …
chymotrypsin (α-CT) and cysteine protease stem bromelain (SB) have prompted significant …
Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor
Z Wu, X Gu, L Zha, Q Yang, Y Zhou, Z Zeng - Structure, 2024 - cell.com
Telomeric repeat-binding factor 1 (Tbf1) has a similar architecture as the TRF family of
telomeric proteins and plays important roles in both telomere homeostasis and ribosome …
telomeric proteins and plays important roles in both telomere homeostasis and ribosome …