Innate immune receptors have a key role in immune surveillance by sensing
microorganisms and initiating protective immune responses. However, the innate immune …

Review underscores the ubiquitous contribution of IFN-δ to immune responses against
malaria, evidence for its protective role and critical issues relating to its induction. Immune …

Background. Elucidating the cellular and molecular basis of naturally acquired immunity to
Plasmodium falciparum infection would assist in developing a rationally based malaria …

The influence of host genetics on susceptibility to Plasmodium falciparum malaria has been
extensively studied over the past twenty years. It is now clear that malaria parasites have …

Cerebral malaria (CM) is a serious complication of Plasmodium falciparum infection that is
responsible for a significant number of deaths in children and nonimmune adults. A failure to …

The human host immune responses to parasitic infections are complex. They can be
categorized into four immunological pathways mounted against four types of parasitic …

Plasmodium falciparum represents one of the strongest selective forces on the human
genome. This stable and perennial pressure has contributed to the progressive …

Background Malaria is a life-threatening disease caused by protozoan parasite of genus
Plasmodium. Various antigenic proteins of Plasmodium are considered as the major targets …

Populations exposed to Plasmodium infection develop genetic mechanisms of protection
against severe disease. The clinical manifestation of malaria results primarily from the lysis …

Africa is the ultimate source of modern humans and as such harbors more genetic variation
than any other continent. For this reason, studies of the patterns of genetic variation in …