We have greatly advanced our ability to grow a diverse range of tissue-derived and
pluripotent stem cell–derived gastrointestinal (GI) tissues in vitro. These systems, broadly …

The cytoskeleton is an interconnected network that provides support and organization to
cells. In eukaryotes, its main components include actin and microtubules, two types of …

The endosomal recycling pathway lies at the heart of the membrane trafficking machinery in
the cell. It plays a central role in determining the composition of the plasma membrane and …

Some patients with microvillus inclusion disease due to myosin 5B (MYO5B) mutations may
develop cholestasis characterized by a progressive familial intrahepatic cholestasis‐like …

Microvillus inclusion disease (MVID) is a disorder of intestinal epithelial differentiation
characterized by life-threatening intractable diarrhea. MVID can be diagnosed based on loss …

Hereditary cholestasis in childhood and infancy with normal serum gamma‐
glutamyltransferase (GGT) activity is linked to several genes. Many patients, however …

Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …

Myosins are among the most fascinating enzymes in biology. As extremely allosteric
chemomechanical molecular machines, myosins are involved in myriad pivotal cellular …

The intestinal epithelium is a highly organized tissue. The establishment of epithelial cell
polarity, with distinct apical and basolateral plasma membrane domains, is pivotal for both …

In epithelial cells, the polarized orientation of the apical–basal axis determines the position
of the apical lumen and, thereby, the collective tubular tissue architecture. From recent …