Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia
into spermatozoa requires the participation of several cell types, hormones, paracrine …

Spermatogenesis is fundamental to the establishment and maintenance of male
reproduction, whereas its abnormality results in male infertility. Somatic cells, including …

There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …

Successful ovulation requires that developmentally competent oocytes are released with
appropriate timing from the ovarian follicle. Somatic cells of the follicle sense the ovulatory …

The LH surge causes major remodeling of the ovarian follicle in preparation for the ovulatory
process. These changes include reprogramming of granulosa cells to differentiate into luteal …

Abstract Insulin-like factor 3 (INSL3) is a small peptide hormone made and secreted
uniquely by mature Leydig cells in the testes of all mammals. Importantly, this expression …

BACKGROUND Leydig cells (LC) are the sites of testicular androgen production.
Development of LC occurs in the testes of most mammalian species as two distinct growth …

Meiotically arrested mammalian oocytes are stimulated to resume meiosis by LH. This
response, which can be reversed by elevation of intraoocyte cAMP levels, is associated with …

Complete testicular descent is a sign of, and a prerequisite for, normal testicular function in
adult life. The process of testis descent is dependent on gubernacular growth and …

Oocyte meiotic maturation is one of the important physiological requirements for species
survival. However, little is known about the detailed events occurring during this process. A …