Pictorial review of glutamate excitotoxicity: fundamental concepts for neuroimaging

LP Mark, RW Prost, JL Ulmer… - American journal …, 2001 - Am Soc Neuroradiology
Neuroradiologists may encounter, on a daily basis, a challenging diversity of neurologic
disorders, including stroke, trauma, epilepsy, and even neurodegenerative conditions, such …

Biology of nitric oxide signaling

L Liaudet, FG Soriano, C Szabó - Critical care medicine, 2000 - journals.lww.com
The free radical nitric oxide (NO) has emerged in recent years as a fundamental signaling
molecule for the maintenance of homeostasis, as well as a potent cytotoxic effector involved …

Neuroprotection and neurodegenerative disease

FJE Vajda - Journal of Clinical Neuroscience, 2002 - Elsevier
This paper will focus on commonalities in the aetiology and pathology in five areas of
neurological disease with illustrative examples of therapy. Possibilities of multimodal and …

Aspartame safety as a food sweetener and related health hazards

SAA Shaher, DF Mihailescu, B Amuzescu - Nutrients, 2023 - mdpi.com
Aspartame is the methyl-ester of the aspartate-phenylalanine dipeptide. Over time, it has
become a very popular artificial sweetener. However, since its approval by the main food …

Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation

A Contestabile, E Ciani - Neurochemistry international, 2004 - Elsevier
Nitric oxide (NO), an important cellular messenger, has been linked to both
neurodegenerative and neuroprotective actions. In the present review, we focus on recent …

Inducible nitric oxide synthase in the rat testis: evidence for potential roles in both normal function and inflammation-mediated infertility

MK O'Bryan, S Schlatt, O Gerdprasert… - Biology of …, 2000 - academic.oup.com
In vitro data have indicated that nitric oxide (NO) inhibits Leydig cell testosterone production,
suggesting that NO may play a role in the suppression of steroidogenesis and …

The role of excitotoxicity in neurodegeneration

E Salińska, W Danysz, JW Łazarewicz - Folia Neuropathologica, 2005 - termedia.pl
A body of evidence suggests that the mechanisms of excitotoxic neuronal damage evoked
by excessive or prolonged activation of the excitatory amino acid receptors may be involved …

[HTML][HTML] Oxidative stress mediates hippocampal neuron death in rats after lithium–pilocarpine-induced status epilepticus

J Liu, A Wang, L Li, Y Huang, P Xue, A Hao - Seizure, 2010 - Elsevier
Oxidative stress, which is defined as the over-production of free radicals, can dramatically
alter neuronal function and has been linked to status epilepticus (SE). The pathological …

Nitric oxide and infectious diseases

D Burgner, K Rockett, D Kwiatkowski - Archives of disease in …, 1999 - adc.bmj.com
Nitric oxide (NO) has undergone something of an image change in recent years. Previously
considered a pollutant from car exhausts, NO has now been implicated in many …

Thioredoxin Catalyzes the Denitrosation of Low-Molecular Mass and Protein S-Nitrosothiols

R Sengupta, SW Ryter, BS Zuckerbraun, E Tzeng… - Biochemistry, 2007 - ACS Publications
While most proteins have critical thiols whose oxidation affects their activity, it has been
suggested that S-nitrosation and denitrosation of cellular thiols are fundamental processes …