Pluripotent stem cells (PSCs) are characterized by their unique capacity for both unlimited
self-renewal and their potential to differentiate to all cell lineages contained within the three …

Pluripotent stem cells can be isolated from embryos or derived by reprogramming.
Pluripotency is stabilized by an interconnected network of pluripotency genes that …

Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic,
as well as germ cells. The epiblast of the early mammalian embryo is the founder population …

STUDY QUESTION How did the field of stem cell research develop in the years following the
derivation of the first human embryonic stem cell (hESC) line? SUMMARY ANSWER …

A major event in embryonic development is the rearrangement of epigenetic information as
the somatic genome is reprogrammed for a new round of organismal development …

Primed and naive human embryonic stem cells (hESCs) do not fully recapitulate the X
chromosome status observed in human preimplantation epiblast and fail to initiate random X …

The naïve state of pluripotency is actively being explored by a number of labs. There is some
controversy in the field as to the true identity of naïve human pluripotent cells as they are not …

The Nm23/NME gene family has been under intensive study since Nm23H1/NME1 was
identified as the first metastasis suppressor. Inverse correlation between the expression …

Although human embryonic stem cells (hESCs) were first derived almost 20 years ago, it
was only recently acknowledged that they share closer molecular and functional identity to …

The successful reprogramming of human somatic cells into induced pluripotent stem cells
(hiPSCs) represented a turning point in the stem cell research field, owing to their ability to …