Reactive oxygen species drive epigenetic changes in radiation‐induced fibrosis

S Shrishrimal, EA Kosmacek… - … medicine and cellular …, 2019 - Wiley Online Library
Radiation‐induced fibrosis (RIF) develops months to years after initial radiation exposure.
RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant …

Space radiation protection countermeasures in microgravity and planetary exploration

CA Montesinos, R Khalid, O Cristea, JS Greenberger… - Life, 2021 - mdpi.com
Background: Space radiation is one of the principal environmental factors limiting the human
tolerance for space travel, and therefore a primary risk in need of mitigation strategies to …

Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling

W Li, L Yin, X Sun, J Wu, Z Dong, K Hu, A Sun… - Cell death & …, 2020 - nature.com
Alpha-lipoic acid (α-LA), a well-known antioxidant, was proved to active ALDH2 in nitrate
tolerance and diabetic animal model. However, the therapeutic advantage of α-LA for heart …

Alpha-lipoic acid effectively attenuates ionizing radiation-mediated testicular dysfunction in rats: Crosstalk of NF-ĸB, TGF-β, and PPAR-ϒ pathways

RS Said, HA Mohamed, DH Kassem - Toxicology, 2020 - Elsevier
Radiotherapy is one of the principal approaches employed in the treatment of pelvic
cancers. Nevertheless, testicular dysfunction and infertility are among the most common …

[HTML][HTML] α-lipoic acid inhibits oxidative stress in testis and attenuates testicular toxicity in rats exposed to carbimazole during embryonic period

P Prathima, K Venkaiah, R Pavani, T Daveedu… - Toxicology reports, 2017 - Elsevier
The aim of this study was to evaluate the probable protective effect of α-lipoic acid against
testicular toxicity in rats exposed to carbimazole during the embryonic period. Time-mated …

Mechanism, prevention, and treatment of radiation-induced salivary gland injury related to oxidative stress

Z Liu, L Dong, Z Zheng, S Liu, S Gong, L Meng, Y Xin… - Antioxidants, 2021 - mdpi.com
Radiation therapy is a common treatment for head and neck cancers. However, because of
the presence of nerve structures (brain stem, spinal cord, and brachial plexus), salivary …

Mitigation of radiation-induced pneumonitis and lung fibrosis using alpha-lipoic acid and resveratrol

R Azmoonfar, P Amini, R Yahyapour… - Anti-Inflammatory & …, 2020 - ingentaconnect.com
Background: Lung is a radiosensitive organ. Studies have shown that exposure of the lung
to acute and high doses of radiation following inhalation of radioactive agents or an …

Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro‐CT analysis

U Aksoy, G Savtekin, AÖ Şehirli… - International …, 2019 - Wiley Online Library
Aim To investigate the possible therapeutic effects of alpha‐lipoic acid (ALA) in a model of
chronic apical periodontitis in rats by analysing biochemical, histopathological and micro …

An investigation of the effects of N-acetylcysteine on radiotherapy-induced testicular injury in rats

A Topcu, F Mercantepe, S Rakici, L Tumkaya… - Naunyn-Schmiedeberg's …, 2019 - Springer
According to data issued by the International Agency for Research on Cancer in 2012, the
estimated number of new cases of all types of cancer worldwide was estimated to exceed 10 …

[HTML][HTML] Evaluating the protective effect of resveratrol, Q10, and alpha-lipoic acid on radiation-induced mice spermatogenesis injury: A histopathological study

M Najafi, M Cheki, P Amini, A Javadi… - International Journal …, 2019 - ncbi.nlm.nih.gov
Background Testis is one of the most sensitive organs against the toxic effect of ionizing
radiation. Exposure to even a low dose of radiation during radiotherapy, diagnostic …