Survey statistics of automated segmentations applied to optical imaging of mammalian cells

P Bajcsy, A Cardone, J Chalfoun, M Halter, D Juba… - BMC …, 2015 - Springer
Background The goal of this survey paper is to overview cellular measurements using
optical microscopy imaging followed by automated image segmentation. The cellular …

Artificial-intelligence-based imaging analysis of stem cells: A systematic scoping review

J Issa, M Abou Chaar, B Kempisty, L Gasiorowski… - Biology, 2022 - mdpi.com
Simple Summary Lately, investigations of artificial intelligence as an assisting tool for
analyzing and identifying stem cells have increased. In this systematic scoping review, we …

Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer

NCW Ho, JYY Yap, Z Zhao, Y Wang… - Advanced …, 2024 - Wiley Online Library
Recently mapped transcriptomic landscapes reveal the extent of heterogeneity in cancer‐
associated fibroblasts (CAFs) beyond previously established single‐gene markers …

Early time-point cell morphology classifiers successfully predict human bone marrow stromal cell differentiation modulated by fiber density in nanofiber scaffolds

D Chen, JP Dunkers, W Losert, S Sarkar - Biomaterials, 2021 - Elsevier
Nanofiber scaffolds can induce osteogenic differentiation and cell morphology alterations of
human bone marrow stromal cells (hBMSCs) without introduction of chemical cues. In this …

Constitutive expression of a fluorescent protein reports the size of live human cells

DF Berenson, E Zatulovskiy, S Xie… - Molecular Biology of …, 2019 - Am Soc Cell Biol
Cell size is important for cell physiology because it sets the geometric scale of organelles
and biosynthesis. A number of methods exist to measure different aspects of cell size, but …

Effect of the scaffold microenvironment on cell polarizability and capacitance determined by probabilistic computations

BAP Betancourt, SJ Florczyk, M Simon… - Biomedical …, 2018 - iopscience.iop.org
In living systems, it is frequently stated that form follows function by virtue of evolutionary
pressures on organism development, but in the study of how functions emerge at the cellular …

Measuring dimensionality of cell‐scaffold contacts of primary human bone marrow stromal cells cultured on electrospun fiber scaffolds

SJ Florczyk, NA Hotaling, M Simon… - … Research Part A, 2023 - Wiley Online Library
The properties and structure of the cellular microenvironment can influence cell behavior.
Sites of cell adhesion to the extracellular matrix (ECM) initiate intracellular signaling that …

A bioinformatics 3D cellular morphotyping strategy for assessing biomaterial scaffold niches

SJ Florczyk, M Simon, D Juba, PS Pine… - ACS Biomaterials …, 2017 - ACS Publications
Many biomaterial scaffolds have been advanced to provide synthetic cell niches for tissue
engineering and drug screening applications; however, current methods for comparing …

Analysis of different computational techniques for calculating the polarizability tensors of stem cells with realistic three-dimensional morphologies

S Baidya, AM Hassan, W Al-Shaikhli… - IEEE Transactions …, 2018 - ieeexplore.ieee.org
Recently, the National Institute of Standards and Technology has developed a database of
three-dimensional (3-D) stem cell morphologies grown in ten different scaffolds to study the …

ESC-Track: A computer workflow for 4-D segmentation, tracking, lineage tracing and dynamic context analysis of ESCs

L Fernández-de-Manúel, C Díaz-Díaz… - …, 2017 - Taylor & Francis
Embryonic stem cells (ESCs) can be established as permanent cell lines, and their potential
to differentiate into adult tissues has led to widespread use for studying the mechanisms and …