Abstract Background The glutamate (Glu) and gamma aminobutyric acid (GABA)
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …

Currently, all treatments for schizophrenia (SCZ) function primarily by blocking D 2-type
dopamine receptors. Given the limitations of these medications, substantial efforts have …

Importance Alterations in glutamatergic neurotransmission may be fundamental to the
pathophysiology of schizophrenia, and the glutamatergic system is a target for novel …

Importance Alterations in glutamatergic neurotransmission have been postulated to be a key
pathophysiologic mechanism in schizophrenia. Objective To evaluate hippocampal …

Findings from neuroimaging studies in patients with schizophrenia suggest widespread
structural changes although the mechanisms through which these changes occur are …

The last fifteen years have seen a great increase in our understanding of the role of
glutamate in schizophrenia (SCZ). The glutamate hypothesis focuses on disturbances in …

Glutamatergic and GABAergic dysfunction are implicated in the pathophysiology of
schizophrenia. Previous work has shown relationships between glutamate, GABA, and brain …

Glutamatergic excitotoxicity is hypothesised to underlie synaptic loss in schizophrenia
pathogenesis, but it is unknown whether synaptic markers are related to glutamatergic …

Epidemiologic, genetic, and neurobiological studies suggest considerable overlap between
schizophrenia and mood disorders. Importantly, both disorders are associated with a broad …

To better characterize hippocampal pathophysiology in schizophrenia, we conducted a
longitudinal study evaluating hippocampal functional connectivity during resting state, using …