Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

The architectural design of our kidneys is amazingly complex, and culminates in the 3D
structure of the glomerular filter. During filtration, plasma passes through a sieve consisting …

Focal segmental glomerulosclerosis (FSGS) is a cause of proteinuric kidney disease,
compromising both native and transplanted kidneys. Treatment is limited because of a …

The pathogenetic mechanisms underlying the onset and the post-transplant recurrence of
primary focal segmental glomerulosclerosis (FSGS) are complex and remain yet to be fully …

Kidney podocytes are highly differentiated epithelial cells that form interdigitating foot
processes with bridging slit diaphragms (SDs) that regulate renal ultrafiltration. Podocyte …

Systemic lupus erythematosus (SLE) is characterized by a broad spectrum of renal lesions.
In lupus glomerulonephritis, histological classifications are based on immune-complex (IC) …

Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms
associated with significant losses of protein in the urine. The glomerular filtration barrier …

Nephrotic syndrome (NS) is a clinical entity characterized by proteinuria, hypoalbuminemia,
and peripheral edema. NS affects about 2–7 per 100,000 children aged below 18 years old …

Minimal change disease (MCD) is the most common type of idiopathic nephrotic syndrome
in childhood and represents about 15% cases in adults. It is characterized by massive …

Anti-cancer therapeutic approaches targeting the vascular endothelial growth factor (VEGF)
ligand (anti-VEGF) or inhibiting its receptors (RTKI) have recently been developed. In spite …