Aging is a biological process characterized by the progressive functional decline of many
interrelated physiological systems. In particular, aging is associated with the development of …

Pathogenic microorganisms entail enormous problems for humans, livestock, and crop
plants. A better understanding of the different infection strategies of the pathogens enables …

An effective and patient-specific feedback control synthesis for inflammation resolution is still
an ongoing research area. A strategy consisting of manipulating a pro and anti-inflammatory …

Emergent responses of the immune system result from the integration of molecular and
cellular networks over time and across multiple organs. High-content and high-throughput …

Agent‐based modeling is a rule‐based, discrete‐event, and spatially explicit computational
modeling method that employs computational objects that instantiate the rules and …

Critical illness, a constellation of interrelated inflammatory and physiological derangements
occurring subsequent to severe infection or injury, affects a large number of individuals in …

When an organism is challenged with a pathogen a cascade of events unfolds. The innate
immune system rapidly mounts a preliminary nonspecific defense, while the acquired …

Understanding the mechanisms that control the body's response to inflammation is of key
importance, due to its involvement in myriad medical conditions, including cancer, arthritis …

Abstract Treatment strategy of a realistic health care system must consider both system and
measurement errors. The traditional optimal control method is commonly applied to …

A mathematical model of the early inflammatory response in transplantation is formulated
with ordinary differential equations. We first consider the inflammatory events associated …