Site-selective protein modification is of significant interest in chemical biology research, with
lysine residues representing a particularly challenging target. Whilst lysines are popular for …

Site-selective acetylation of a single lysine residue in a protein that reaches a lysine
acetyltransferase's accuracy, precision, and reliability is challenging. Here, we report a …

Chemical modification of native peptides and proteins is a versatile strategy to facilitate late-
stage diversification for functional studies. Among the proteogenic amino acids, lysine is …

Synthetic molecules that form a covalent bond upon binding to a targeted biomolecule
(proximity-induced reactivity) are the subject of intense biomedical interest for the unique …

Displaying antibodies on carrier surfaces facilitates precise targeting and delivery of drugs to
diseased cells. Here, we report the synthesis of antibody-lipid conjugates (ALCs) through …

A critical problem in the fight against bacterial infection is the rising rates of resistance and
the lack of new antibiotics. The discovery of new targets or new antibacterial mechanisms is …

Utilizing small molecules as markers for specific cells or organs within biosystems is a
crucial approach for studying and regulating physiological processes. However, current …

Within the scope of accurate structure‐property correlations in biomolecules, this work
investigates how conformations and electronic configurations of biologically relevant …

Attaching proteins to surfaces while maintaining bioactivity is a promising avenue for
developing new functional materials. This work describes a method to rapidly apply …

In vivo receptor targeting with radiolabelled peptide‐based probes is an attractive approach
for the development of novel radiotracers for molecular imaging. This work presents the …