Apolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE
is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other …

The ε4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for
Alzheimer's disease (AD) and several other neurodegenerative conditions, including Lewy …

The major genetic risk factor for Alzheimer's disease (AD), APOE4, accelerates beta-amyloid
(Aβ) plaque formation, but whether this is caused by APOE expressed in microglia or …

Tauopathies are a collection of neurodegenerative diseases characterized by the
accumulation of pathogenic aggregates of the microtubule‐associated protein tau. Despite …

Loss-of-function mutations in the X-linked endosomal Na+/H+ exchanger 6 (NHE6) cause
Christianson syndrome in males. Christianson syndrome involves endosome dysfunction …

The APOE gene encoding the Apolipoprotein E protein is the single most significant genetic
risk factor for late‐onset Alzheimer's disease. The APOE4 genotype confers a significantly …

Endocytosis is a key cellular pathway required for the internalization of cellular nutrients,
lipids and receptor-bound cargoes. It is also critical for the recycling of cellular components …

Disruption of endolysosomal and autophagy-lysosomal systems is increasingly implicated in
neurodegeneration. Sodium-proton exchanger 6 (NHE6) contributes to the maintenance of …

Alzheimer's disease (AD) is the most common neurodegenerative disorder and one of the
leading causes of disability worldwide. The apolipoprotein E4 gene (APOE4) is the strongest …

The circadian rhythm is a 24 h internal clock within the body that regulates various factors,
including sleep, body temperature, and hormone secretion. Circadian rhythm disruption is …