PEGylated lipid nanoparticle formulations: immunological safety and efficiency perspective

R Tenchov, JM Sasso, QA Zhou - Bioconjugate chemistry, 2023 - ACS Publications
Lipid nanoparticles (LNPs) have been recognized as efficient vehicles to transport a large
variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 …

Stealth nanoparticles in oncology: Facing the PEG dilemma

S Zalba, TLM Ten Hagen, C Burgui… - Journal of Controlled …, 2022 - Elsevier
Nanoparticles (Nps) have revolutionized the landscape of many treatments, by modifying not
only pharmacokinetic properties of the encapsulated agent, but also providing a significant …

Block copolymer micelles in nanomedicine applications

H Cabral, K Miyata, K Osada, K Kataoka - Chemical reviews, 2018 - ACS Publications
Polymeric micelles are demonstrating high potential as nanomedicines capable of
controlling the distribution and function of loaded bioactive agents in the body, effectively …

A comprehensive review on novel liposomal methodologies, commercial formulations, clinical trials and patents

VVSNL Andra, SVN Pammi, LVKP Bhatraju… - Bionanoscience, 2022 - Springer
Liposomes are well-recognized and essential nano-sized drug delivery systems. Liposomes
are phospholipid vesicles comprised of cell membrane components and have been …

[HTML][HTML] Recent advances in long-acting drug delivery systems for anticancer drug

C Pacheco, A Baiao, T Ding, W Cui… - Advanced Drug Delivery …, 2023 - Elsevier
The use of systemic anticancer chemotherapy is intrinsically limited by its toxicity. Whether
dealing with small molecules or biopharmaceuticals, after systemic administration, small …

Magnetic nanoparticles in targeted drug delivery: a review

E Kianfar - Journal of Superconductivity and Novel Magnetism, 2021 - Springer
Magnetic nanoparticles are one of the most important and widely used types of
nanomaterials, whose unique properties make them special compared to other …

[HTML][HTML] Polyethylenimine (PEI) in gene therapy: Current status and clinical applications

J Casper, SH Schenk, E Parhizkar, P Detampel… - Journal of Controlled …, 2023 - Elsevier
Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

Recent advancements in polymer/liposome assembly for drug delivery: From surface modifications to hybrid vesicles

V De Leo, F Milano, A Agostiano, L Catucci - Polymers, 2021 - mdpi.com
Liposomes are consolidated and attractive biomimetic nanocarriers widely used in the field
of drug delivery. The structural versatility of liposomes has been exploited for the …

Antibiofouling polymer interfaces: poly (ethylene glycol) and other promising candidates

S Lowe, NM O'Brien-Simpson, LA Connal - Polymer Chemistry, 2015 - pubs.rsc.org
Nonspecific protein adsorption and/or microbial adsorption on biomedical materials
adversely affects the efficacy of a range of biomedical systems, from implants and …

Emerging research and clinical development trends of liposome and lipid nanoparticle drug delivery systems

JC Kraft, JP Freeling, Z Wang, RJY Ho - Journal of pharmaceutical …, 2014 - Elsevier
Liposomes are spherical-enclosed membrane vesicles mainly constructed with lipids. Lipid
nanoparticles are loaded with therapeutics and may not contain an enclosed bilayer. The …