Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Natural metalloproteins perform many functions—ranging from sensing to electron transfer
and catalysis—in which the position and property of each ligand and metal are dictated by …

Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …

One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Metalloproteins perform a variety of functions in biological systems. The catalysis of several
remarkable chemical transformations occurs at metal centers embedded in the active sites of …

Conspectus De novo protein design represents an attractive approach for testing and
extending our understanding of metalloprotein structure and function. Here, we describe our …

The rational design of artificial enzymes, either by applying physico–chemical intuition of
protein structure and function or with the aid of computational methods, is a promising area …

Many efforts are being made in the design and engineering of metalloenzymes with catalytic
properties fulfilling the needs of practical applications. Progress in this field has recently …

The de novo design of catalytic proteins provides a stringent test of our understanding of
enzyme function, while simultaneously laying the groundwork for the design of novel …