Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Abstract N-methyl-d-aspartate (NMDA) receptors are Hebbian-like coincidence detectors,
requiring binding of glycine and glutamate in combination with the relief of voltage …

Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central
nervous system and function by opening a transmembrane ion channel upon binding of …

NMDA receptors (NMDARs) form glutamate‐gated ion channels widely expressed in the
central nervous system and highly permeable to calcium ions. NMDARs have always …

Glutamate (Glu) is the primary excitatory transmitter in the mammalian brain. But, we know
little about the evolutionary history of this adaptation, including the selection of l-glutamate …

Since it was discovered that the anti-hypertensive agent ifenprodil has neuroprotective
activity through its effects on NMDA (N-methyl-D-aspartate) receptors, a determined effort …

Two decades have passed since the first report of the cloning of a kainate-type glutamate
receptor (KAR) subunit. The intervening years have seen a rapid growth in our …

Human GABAB (γ-aminobutyric acid class B) receptor is a G-protein-coupled receptor
central to inhibitory neurotransmission in the brain. It functions as an obligatory heterodimer …

NMDA receptors comprised of different NR2 subunits exhibit strikingly unique biophysical
and pharmacological properties. Here, we report that the extracellular amino-terminal …