Cannabinoid receptors, endocannabinoids and the enzymes responsible for their
biosynthesis and degradation constitute the endocannabinoid system. In recent decades …

Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …

Extracellular vesicles (EVs) have emerged as important mediators of intercellular
communication and as possible therapeutic agents in inflammation-mediated demyelinating …

Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of
physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most …

Myelin is the lipid-rich structure formed by oligodendrocytes (OLs) that wraps the axons in
multilayered sheaths, assuring protection, efficient saltatory signal conduction and metabolic …

Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible
for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2 …

Neurological disorders such as neurodegenerative diseases or traumatic brain injury are
associated with cognitive, motor and behavioural changes that influence the quality of life of …

Stroke is the second leading cause of death worldwide and has two major subtypes:
ischemic stroke and hemorrhagic stroke. Neuroinflammation is a pathological hallmark of …

Graphdiyne (GDY) is a kind of nanomaterial from the graphene carbon family with excellent
physical and chemical properties. Despite some applications in medical engineering, GDY …

Cannabinoid-based interventions are being explored for central nervous system (CNS)
pathologies such as neurodegeneration, demyelination, epilepsy, stroke, and trauma. As …