Importance of thymoquinone, sulforaphane, phloretin, and epigallocatechin and their health benefits

MH Shahrajabian, W Sun - Letters in Drug Design & Discovery, 2024 - benthamdirect.com
Natural products have a broad diversity of multidimensional chemical formations, which play
an important role, and indicate the crucial nature as a golden source for gaining herbal drug …

Dietary isothiocyanates inhibit cancer progression by modulation of epigenome

MK Sundaram, R Preetha, S Haque, N Akhter… - Seminars in Cancer …, 2022 - Elsevier
Cell cycle, growth, survival and metabolism are tightly regulated together and failure in
cellular regulation leads to carcinogenesis. Several signaling pathways like the PI3K, WNT …

Identification and validation of cuproptosis-related prognostic signature and associated regulatory axis in uterine corpus endometrial carcinoma

Y Chen - Frontiers in genetics, 2022 - frontiersin.org
Background: Uterine corpus endometrial carcinoma (UCEC) is a common gynecological
malignancy globally with high recurrence and mortality rates. Cuproptosis is a new type of …

CDKN2A-mediated molecular subtypes characterize the hallmarks of tumor microenvironment and guide precision medicine in triple-negative breast cancer

T Cheng, Y Wu, Z Liu, Y Yu, S Sun, M Guo… - Frontiers in …, 2022 - frontiersin.org
Currently, breast cancer (BRCA) has become the most common cancer in the world, whose
pathological mechanism is complex. Among its subtypes, triple-negative breast cancer …

Dietary antioxidants remodel DNA methylation patterns in chronic disease

M Beetch, S Harandi‐Zadeh, K Shen… - British journal of …, 2020 - Wiley Online Library
Chronic diseases account for over 60% of all deaths worldwide according to the World
Health Organization reports. Majority of cases are triggered by environmental exposures that …

The glucosinolates: a sulphur glucoside family of mustard anti-tumour and antimicrobial phytochemicals of potential therapeutic application

J Melrose - Biomedicines, 2019 - mdpi.com
This study reviewed aspects of the biology of two members of the glucosinolate family,
namely sinigrin and glucoraphanin and their anti-tumour and antimicrobial properties …

Harnessing Sulforaphane Potential as a Chemosensitizing Agent: A Comprehensive Review

BL Sailo, L Liu, S Chauhan, S Girisa, M Hegde, L Liang… - Cancers, 2024 - mdpi.com
Simple Summary Recent oncological research highlights the promising role of naturally
derived compounds in cancer prevention and treatment. Sulforaphane (SFN), a …

Prospective epigenetic actions of organo-sulfur compounds against cancer: perspectives and molecular mechanisms

S Shoaib, MA Ansari, M Ghazwani, U Hani, YF Jamous… - Cancers, 2023 - mdpi.com
Simple Summary Epigenetics has provided a new dimension to our understanding of cancer
initiation and progression. Unlike the genetic changes in DNA sequence, abnormal …

TIGD1 function as a potential cuproptosis regulator following a novel cuproptosis-related gene risk signature in colorectal cancer

Z Wu, C Lin, F Zhang, Z Lu, Y Wang, Y Liu, Z Zhou, L Li… - Cancers, 2023 - mdpi.com
Simple Summary This study investigates the role of cuproptosis, a type of programmed cell
death that depends on copper, in the progression of colorectal cancer (CRC). Using …

Mitochondrial DNA and neurodegeneration: any role for dietary antioxidants?

L Bordoni, R Gabbianelli - Antioxidants, 2020 - mdpi.com
The maintenance of the mitochondrial function is essential in preventing and counteracting
neurodegeneration. In particular, mitochondria of neuronal cells play a pivotal role in …