Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed,
protein-serine/threonine kinases, which participate in signal transduction pathways that …

Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK)
cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four …

The NLRP3 inflammasome can sense different pathogens or danger signals, and has been
reported to be involved in the development of many human diseases. Potassium efflux and …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

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Mitogen-activated protein (MAP) kinases are a family of serine/threonine kinases that play a
central role in transducing extracellular cues into a variety of intracellular responses ranging …

Ion channels are integral membrane proteins present on the plasma membrane as well as
intracellular membranes. In the human genome, there are more than 400 known genes …

The ubiquitous glutathione transferases (GSTs) catalyze glutathione conjugation to many
compounds and have other diverse functions that continue to be discovered. We noticed …

Fetal lung underdevelopment, also known as pulmonary hypoplasia, is characterized by
decreased lung growth and maturation. The most common birth defect found in babies with …

CLIC1 (NCC27) is a member of the highly conserved class of chloride ion channels that
exists in both soluble and integral membrane forms. Purified CLIC1 can integrate into …