Capping protein regulators fine-tune actin assembly dynamics

M Edwards, A Zwolak, DA Schafer, D Sept… - … reviews Molecular cell …, 2014 - nature.com
Capping protein (CP) binds the fast growing barbed end of the actin filament and regulates
actin assembly by blocking the addition and loss of actin subunits. Recent studies provide …

CK2 regulation: perspectives in 2021

SE Roffey, DW Litchfield - Biomedicines, 2021 - mdpi.com
The protein kinase CK2 (CK2) family encompasses a small number of acidophilic
serine/threonine kinases that phosphorylate substrates involved in numerous biological …

Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2

JS Duncan, DW Litchfield - Biochimica et Biophysica Acta (BBA)-Proteins …, 2008 - Elsevier
CK2 is a highly conserved protein serine/threonine kinase that is ubiquitously distributed in
eukaryotes, constitutively active and has been implicated in multiple cellular functions, as …

New insights into mechanism and regulation of actin capping protein

JA Cooper, D Sept - International review of cell and molecular biology, 2008 - Elsevier
The heterodimeric actin capping protein, referred to here as “CP,” is an essential element of
the actin cytoskeleton, binding to the barbed ends of actin filaments and regulating their …

Identification of differentially expressed microRNAs by microarray: a possible role for microRNA genes in pituitary adenomas

A Bottoni, MC Zatelli, M Ferracin… - Journal of cellular …, 2007 - Wiley Online Library
MicroRNAs (miRNAs) are small non‐coding RNAs that control gene expression by targeting
mRNA. It has been demonstrated that miRNA expression is altered in many human cancers …

Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation

B de Jonckheere, F Kollotzek, P Münzer… - Nature cardiovascular …, 2023 - nature.com
During megakaryopoiesis, megakaryocytes (MKs) undergo cellular morphological changes
with strong modification of membrane composition and lipid signaling. Here, we adopt a lipid …

Order or chaos? An evaluation of the regulation of protein kinase CK2

MEK Olsten, DW Litchfield - Biochemistry and cell biology, 2004 - cdnsciencepub.com
CK2 is a highly conserved, ubiquitously expressed protein serine/threonine kinase present
in all eukaryotes. Circumscribed as having a vast array of substrates located in a number of …

Kinase CK2 inhibition: an update

G Cozza, LA Pinna, S Moro - Current medicinal chemistry, 2013 - ingentaconnect.com
Protein kinase CK2 (Casein Kinase 2) is an essential, ubiquitous and highly pleiotropic
protein kinase, implicated in several human diseases. In the last decade, several inhibitors …

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice …

W Gong, J Li, Z Chen, J Huang, Q Chen, W Cai… - Free Radical Biology …, 2017 - Elsevier
Our previous study indicated that Casein kinase 2 interacting protein-1 (CKIP-1) could
promote the activation of the nuclear factor E2-related factor 2 (Nrf2)/antioxidant response …

Protein kinase CK2, an important regulator of the inflammatory response?

NN Singh, DP Ramji - Journal of molecular medicine, 2008 - Springer
Abstract Casein kinase 2 (CK2) is a highly conserved serine–threonine kinase that uses
both adenosine triphosphate and guanosine triphosphate as phosphate donors. This …