Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …

Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Diabetic kidney disease (DKD) occurs in∼ 40% of patients with diabetes and causes kidney
failure, cardiovascular disease, and premature death. We analyzed the response of a …

Formalin-fixed paraffin-embedded (FFPE) tissues constitute a vast and valuable patient
material bank for clinical history and follow-up data. It is still challenging to achieve single …

The blood–brain barrier (BBB) protects the brain and maintains neuronal homeostasis. BBB
properties can vary between brain regions to support regional functions, yet how BBB …

Mesangial cells are stromal cells that are important for kidney glomerular homeostasis and
the glomerular response to injury. A growing body of evidence demonstrates that …

The field of single-cell genomics and spatial technologies is rapidly evolving and has
already provided unprecedented insights into complex tissues. Major advances have been …

Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney
tissue atlas in health and disease with single-cell resolution. Here, we describe the …

Tissue regeneration is limited in several organs, including the kidney, contributing to the
high prevalence of kidney disease globally. However, evolutionary and physiological …

The development of lupus nephritis is multifactorial involving genetic susceptibility,
environmental triggers and systemic inflammation. However, the role of resident kidney cells …