Harnessing genomic information for livestock improvement
M Georges, C Charlier, B Hayes - Nature Reviews Genetics, 2019 - nature.com
The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …
2050. Meeting this demand in a way that has a minimal impact on the environment will …
Dissecting the genetics of complex traits using summary association statistics
B Pasaniuc, AL Price - Nature reviews genetics, 2017 - nature.com
During the past decade, genome-wide association studies (GWAS) have been used to
successfully identify tens of thousands of genetic variants associated with complex traits and …
successfully identify tens of thousands of genetic variants associated with complex traits and …
Integrative approaches for large-scale transcriptome-wide association studies
Many genetic variants influence complex traits by modulating gene expression, thus altering
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …
the abundance of one or multiple proteins. Here we introduce a powerful strategy that …
Concepts, estimation and interpretation of SNP-based heritability
Abstract Narrow-sense heritability (h 2) is an important genetic parameter that quantifies the
proportion of phenotypic variance in a trait attributable to the additive genetic variation …
proportion of phenotypic variance in a trait attributable to the additive genetic variation …
[HTML][HTML] Systematic identification of genetic influences on methylation across the human life course
Background The influence of genetic variation on complex diseases is potentially mediated
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …
Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection
Recent work has hinted at the linkage disequilibrium (LD)-dependent architecture of human
complex traits, where SNPs with low levels of LD (LLD) have larger per-SNP heritability …
complex traits, where SNPs with low levels of LD (LLD) have larger per-SNP heritability …
Reevaluation of SNP heritability in complex human traits
SNP heritability, the proportion of phenotypic variance explained by SNPs, has been
reported for many hundreds of traits. Its estimation requires strong prior assumptions about …
reported for many hundreds of traits. Its estimation requires strong prior assumptions about …
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index
We propose a method (GREML-LDMS) to estimate heritability for human complex traits in
unrelated individuals using whole-genome sequencing data. We demonstrate using …
unrelated individuals using whole-genome sequencing data. We demonstrate using …
[PDF][PDF] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to …
genome-wide association studies (GWASs) of complex disease, but their contributions to …
Defining the role of common variation in the genomic and biological architecture of adult human height
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-
wide significance that together explained one-fifth of the heritability for adult height. By …
wide significance that together explained one-fifth of the heritability for adult height. By …