Recent advances in isobaric labeling and applications in quantitative proteomics

MK Sivanich, TJ Gu, DN Tabang, L Li - Proteomics, 2022 - Wiley Online Library
Mass spectrometry (MS) has emerged at the forefront of quantitative proteomic techniques.
Liquid chromatography‐mass spectrometry (LC‐MS) can be used to determine abundances …

Recent advances in analytical approaches for glycan and glycopeptide quantitation

DG Delafield, L Li - Molecular & Cellular Proteomics, 2021 - ASBMB
Growing implications of glycosylation in physiological occurrences and human disease have
prompted intensive focus on revealing glycomic perturbations through absolute and relative …

Quadruplex stable isotope derivatization strategy for the determination of panaxadiol and panaxatriol in foodstuffs and medicinal materials using ultra high …

S Zhu, Z Zheng, H Peng, J Sun, XE Zhao… - Journal of Chromatography …, 2020 - Elsevier
This work proposed a novel strategy based on quadruplex stable isotope derivatization for
sensitive, accurate, speedy and green determination of panaxadiol (PD) and panaxatriol …

On-tissue derivatization with Girard's reagent P enhances N-glycan signals for formalin-fixed paraffin-embedded tissue sections in MALDI mass spectrometry imaging

H Zhang, X Shi, NQ Vu, G Li, Z Li, Y Shi, M Li… - Analytical …, 2020 - ACS Publications
Glycosylation is a major protein post-translational modification whose dysregulation has
been associated with many diseases. Herein, an on-tissue chemical derivatization strategy …

Advances in mass spectrometry‐based glycomics—An update covering the period 2017–2021

KB Donohoo, J Wang, M Goli, A Yu, W Peng… - …, 2022 - Wiley Online Library
The wide variety of chemical properties and biological functions found in proteins is attained
via post‐translational modifications like glycosylation. Covalently bonded to proteins …

High-throughput relative quantification of fatty acids by 12-plex isobaric labeling and microchip capillary electrophoresis-Mass spectrometry

Z Wang, M Li, S Xu, L Sun, L Li - Analytica Chimica Acta, 2024 - Elsevier
Abstract Background Fatty acids (FAs) are essential cellular components and play important
roles in various biological processes. Importantly, FAs produced by microorganisms from …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2019–2020

DJ Harvey - Mass Spectrometry Reviews, 2023 - Wiley Online Library
This review is the tenth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of …

Quantitative Analysis and Structural Elucidation of Fatty Acids by Isobaric Multiplex Labeling Reagents for Carbonyl-Containing Compound (SUGAR) Tags and m …

Y Feng, Y Lv, TJ Gu, B Chen, L Li - Analytical chemistry, 2022 - ACS Publications
In this study, a novel analytical method was developed to investigate fatty acids (FAs) for
relative quantification, carbon–carbon double-bond localization, and cis-/trans-geometry …

6-Plex mdSUGAR Isobaric-Labeling Guide Fingerprint Embedding for Glycomics Analysis

M Ma, M Li, Y Zhu, Y Zhao, F Wu, Z Wang… - Analytical …, 2023 - ACS Publications
Glycans are vital biomolecules with diverse functions in biological processes. Mass
spectrometry (MS) has become the most widely employed technology for glycomics studies …

High-throughput quantitative glycomics enabled by 12-plex isobaric multiplex labeling reagents for carbonyl-containing compound (SUGAR) tags

M Li, Y Feng, M Ma, A Kapur… - Journal of proteome …, 2023 - ACS Publications
Glycans, which are widely distributed on most proteins and cell surfaces, are a class of
important biomolecules playing crucial roles in various biological processes such as …