Alzheimer's disease (AD) research has entered a new era with the recent positive phase 3
clinical trials of the anti-Aβ antibodies lecanemab and donanemab. Why did it take 30 years …

Dementia, a prevalent condition among older individuals, has profound societal
implications. Extensive research has resulted in no cure for what is perceived as the most …

An international consensus report in 2019 recommended a classification system for limbic-
predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) …

Although loss of TAR DNA-binding protein 43 kDa (TDP-43) splicing repression is well
documented in postmortem tissues of amyotrophic lateral sclerosis (ALS) and frontotemporal …

Abstract Background Most Alzheimer's Disease (AD) cases also exhibit limbic predominant
age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), besides …

Background Population-based autopsy studies provide valuable insights into the causes of
dementia but are limited by sample size and restriction to specific populations …

LATE-NC, the neuropathologic changes of limbic-predominant age-related TAR DNA-
binding protein 43 kDa (TDP-43) encephalopathy are frequently associated with Alzheimer's …

Nuclear clearance and cytoplasmic accumulations of the RNA-binding protein TDP-43 are
pathological hallmarks in almost all patients with amyotrophic lateral sclerosis (ALS) and up …

Hippocampal sclerosis (HS) is associated with advanced age as well as transactive
response DNA-binding protein with 43 kDa (TDP-43) deposits. Both hippocampal sclerosis …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the loss of upper and lower motor neurons. Presently, three FDA-approved drugs are …