Single‐cell analysis using droplet microfluidics
Droplet microfluidics has revolutionized the study of single cells. The ability to
compartmentalize cells within picoliter droplets in microfluidic devices has opened up a wide …
compartmentalize cells within picoliter droplets in microfluidic devices has opened up a wide …
Advances and opportunities in single-cell transcriptomics for plant research
C Seyfferth, J Renema, JR Wendrich… - Annual Review of …, 2021 - annualreviews.org
Single-cell approaches are quickly changing our view on biological systems by increasing
the spatiotemporal resolution of our analyses to the level of the individual cell. The field of …
the spatiotemporal resolution of our analyses to the level of the individual cell. The field of …
Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …
High-dimensional single-cell analysis of human natural killer cell heterogeneity
L Rebuffet, JE Melsen, B Escalière… - Nature …, 2024 - nature.com
Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to
microbes and tumors. Historically, their classification hinged on a limited array of surface …
microbes and tumors. Historically, their classification hinged on a limited array of surface …
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation
Macrophages are central orchestrators of the tissue response to injury, with distinct
macrophage activation states playing key roles in fibrosis progression and resolution …
macrophage activation states playing key roles in fibrosis progression and resolution …
[HTML][HTML] Doublet identification in single-cell sequencing data using scDblFinder
Doublet identification in single-cell sequencing data using scDblFinder - PMC Back to Top
Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main …
Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main …
A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation
The mutualistic relationship of gut-resident microbiota and the host immune system
promotes homeostasis that ensures maintenance of the microbial community and of a …
promotes homeostasis that ensures maintenance of the microbial community and of a …
Integrated analysis of multimodal single-cell data
Y Hao, S Hao, E Andersen-Nissen, WM Mauck… - Cell, 2021 - cell.com
The simultaneous measurement of multiple modalities represents an exciting frontier for
single-cell genomics and necessitates computational methods that can define cellular states …
single-cell genomics and necessitates computational methods that can define cellular states …
Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells
EP Mimitou, CA Lareau, KY Chen… - Nature …, 2021 - nature.com
Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …
Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification
Immunotherapy is a mainstay of non-small cell lung cancer (NSCLC) management. While
tumor mutational burden (TMB) correlates with response to immunotherapy, little is known …
tumor mutational burden (TMB) correlates with response to immunotherapy, little is known …