Chromosomal rearrangements involving the NTRK1, NTRK2, and NTRK3 genes (NTRK
genes), which encode the high-affinity nerve growth factor receptor (TRKA), brain-derived …

Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of secreted
growth factors and binds with high affinity to the TrkB tyrosine kinase receptors. BDNF is a …

Background Neuroblastoma is a devastating disease accounting for 15% of all childhood
cancer deaths. Yet, our understanding of key molecular drivers such as receptor tyrosine …

The NTRK genes encode the tropomyosin-related receptor tyrosine kinases TrkA, TrkB and
TrkC. TRK receptors regulate the proliferation, differentiation, and survival of many neuronal …

Stem cell-like brain tumor initiating cells (BTICs) cause recurrence of glioblastomas, with
BTIC 'stemness' affected by epigenetic mechanisms. The ING family of epigenetic regulators …

Pathogenic variations in the NTRK1 can cause congenital insensitivity to pain with
anhidrosis (CIPA), a rare autosomal recessive inherited neuropathy. The precise diagnosis …

Signaling functions of plasma membrane-localized receptor tyrosine kinases (RTKs) have
been extensively studied after they were first described in the mid-1980s. Plasma membrane …

Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive
disorder, characterized by loss of algesthesis and inability to sweat. CIPA is known to be …

Chronic pain is a major health issue, and the search for new analgesics has become
increasingly important because of the addictive properties and unwanted side effects of …

Oncogenes derived from the neurotrophin receptor tropomyosin-related kinase TrkA act as
drivers in sub-populations of a wide-range of human cancers. This, combined with a recent …