As our knowledge of the structure and functions of fibrinogen and fibrin has increased
tremendously, several key findings have given some people a superficial impression that the …

As the third most common vascular disease, venous thromboembolism is associated with
significant mortality and morbidity. Pathogenesis underlying venous thrombosis is still not …

Congenital fibrinogen disorders (CFDs) are a heterogeneous group of rare inherited
abnormalities of blood coagulation 1. CFDs result from monoallelic or biallelic mutations in …

Congenital fibrinogen disorders are rare diseases affecting either the quantity
(afibrinogenemia and hypofibrinogenemia) or the quality (dysfibrinogenemia) or both …

Fibrinogen is a hexameric plasmatic glycoprotein composed of pairs of three chains (Aα, Bβ,
and γ), which play an essential role in hemostasis. Conversion of fibrinogen to insoluble …

BACKGROUND Fibrinogen is a large (340 kDa) hexameric glycoprotein expressed by
hepatocytes. 1 Fibrinogen is encoded by 3 different genes (FGA, FGB, and FGG) and …

Congenital fibrinogen disorders can be quantitative (afibrinogenemia, hypofibrinogenemia)
or functional (dysfibrinognemia). To date, several genetic variants have been identified in …

Fibrinogen is a complex protein that plays a key role in the blood clotting process. It is a
hexamer composed of two copies of three distinct chains: Aα, Bβ, and γ encoded by three …

Congenital dysfibrinogenemia (CD) is caused by structural changes in fibrinogen that modify
its function. Diagnosis is based on discrepancy between decreased fibrinogen activity and …

The study of inherited fibrinogen disorders, characterized by extensive allelic heterogeneity,
allows the association of defined mutations with specific defects providing significant insight …