Diabetic macular edema: current understanding, molecular mechanisms and therapeutic implications

J Zhang, J Zhang, C Zhang, J Zhang, L Gu, D Luo… - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), with increasing incidence, is the major cause of vision loss and
blindness worldwide in working-age adults. Diabetic macular edema (DME) remains the …

The blood–retina barrier in health and disease

F O'Leary, M Campbell - The FEBS journal, 2023 - Wiley Online Library
The blood–retina barrier (BRB) is the term used to define the properties of the retinal
capillaries and the retinal pigment epithelium (RPE), which separate the systemic circulation …

Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE) …

CC Wykoff, F Abreu, AP Adamis, K Basu… - The Lancet, 2022 - thelancet.com
Background To reduce treatment burden and optimise patient outcomes in diabetic macular
oedema, we present 1-year results from two phase 3 trials of faricimab, a novel angiopoietin …

Role of inflammation in diabetic retinopathy

A Rübsam, S Parikh, PE Fort - International journal of molecular sciences, 2018 - mdpi.com
Diabetic retinopathy is a common complication of diabetes and remains the leading cause of
blindness among the working-age population. For decades, diabetic retinopathy was …

[HTML][HTML] KESTREL and KITE: 52-week results from two phase III pivotal trials of brolucizumab for diabetic macular edema

DM Brown, A Emanuelli, F Bandello… - American journal of …, 2022 - Elsevier
Purpose To compare the efficacy and safety of brolucizumab with aflibercept in patients with
diabetic macular edema (DME). Design Double-masked, 100-week, multicenter, active …

Guidelines for the management of retinal vein occlusion by the European Society of Retina Specialists (EURETINA)

U Schmidt-Erfurth, J Garcia-Arumi, BS Gerendas… - …, 2019 - karger.com
The high prevalence of cardiovascular disease particularly in the elderly population is
associated with retinal vascular disease. Retinal vein occlusions represent severe …

VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy

A Arrigo, E Aragona, F Bandello - Annals of medicine, 2022 - Taylor & Francis
Diabetic retinopathy (DR) is the most common microangiopathic complication of diabetes
mellitus, representing a major cause of visual impairment in developed countries …

OCT angiography metrics predict progression of diabetic retinopathy and development of diabetic macular edema: a prospective study

Z Sun, F Tang, R Wong, J Lok, SKH Szeto, JCK Chan… - Ophthalmology, 2019 - Elsevier
Purpose To prospectively determine the relationship of OCT angiography (OCTA) metrics to
diabetic retinopathy (DR) progression and development of diabetic macular edema (DME) …

Photoreceptor cells and RPE contribute to the development of diabetic retinopathy

D Tonade, TS Kern - Progress in retinal and eye research, 2021 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as
vascular disease, but work in the past years has shown abnormalities also in the neural …

Pathophysiology of diabetic retinopathy: the old and the new

S Kusuhara, Y Fukushima, S Ogura… - Diabetes & …, 2018 - synapse.koreamed.org
Vision loss in diabetic retinopathy (DR) is ascribed primarily to retinal vascular abnormalities—
including hyperpermeability, hypoperfusion, and neoangiogenesis—that eventually lead to …