Use of zebrafish in drug discovery toxicology

S Cassar, I Adatto, JL Freeman, JT Gamse… - Chemical research in …, 2019 - ACS Publications
Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

[HTML][HTML] Emerging organic contaminants in karst groundwater: A global level assessment

JL Reberski, J Terzić, LD Maurice, DJ Lapworth - Journal of Hydrology, 2022 - Elsevier
A quarter of the world's population uses groundwater from karst aquifers. A range of
emerging organic contaminants (EOCs) are considered a potential threat to water resources …

Metabolomic profiling reveals the intestinal toxicity of different length of microplastic fibers on zebrafish (Danio rerio)

Y Zhao, R Qiao, S Zhang, G Wang - Journal of Hazardous Materials, 2021 - Elsevier
To explore the intestinal toxicity of microplastic fibers, zebrafish larvae and adults were
exposed to different length of microplastic fibers (50±26 μm and 200±90 μm). After …

[HTML][HTML] Biological effect and chemical monitoring of Watch List substances in European surface waters: steroidal estrogens and diclofenac–effect-based methods for …

E Simon, A Duffek, C Stahl, M Frey, M Scheurer… - Environment …, 2022 - Elsevier
rationale of the study Three steroidal estrogens, 17α-ethinylestradiol (EE2), 17β-estradiol
(E2), estrone (E1), and the non-steroidal anti-inflammatory drug (NSAID), diclofenac have …

[图书][B] Bioanalytical tools in water quality assessment

P Neale, F Leusch, B Escher - 2021 - library.oapen.org
The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012.
The field has exploded since and the second edition updates and reviews the application of …

Emerging contaminants in South African water environment-a critical review of their occurrence, sources and ecotoxicological risks

KM Gani, N Hlongwa, T Abunama, S Kumari, F Bux - Chemosphere, 2021 - Elsevier
The release of emerging contaminants (ECs) to the environment is a serious concern due to
its health implications on humans, aquatic species, and the development of anti-microbial …

A critical review on quantitative evaluation of aqueous toxicity in water quality assessment

L Zhang, Y Zhang, M Zhu, L Chen, B Wu - Chemosphere, 2023 - Elsevier
Conventional chemical techniques have inherent limitations in detecting unknown chemical
substances in water. As a result, effect-based methods have emerged as a viable alternative …

[HTML][HTML] Towards a systematic use of effect biomarkers in population and occupational biomonitoring

MZ Jeddi, NB Hopf, S Viegas, AB Price, A Paini… - Environment …, 2021 - Elsevier
Abstract Effect biomarkers can be used to elucidate relationships between exposure to
environmental chemicals and their mixtures with associated health outcomes, but they are …

[HTML][HTML] Towards regulation of Endocrine Disrupting chemicals (EDCs) in water resources using bioassays–A guide to developing a testing strategy

J Robitaille, ND Denslow, BI Escher… - Environmental …, 2022 - Elsevier
Endocrine disrupting chemicals (EDCs) are found in every environmental medium and are
chemically diverse. Their presence in water resources can negatively impact the health of …

Application of effect-based methods to water quality monitoring: Answering frequently asked questions by water quality managers, regulators, and policy makers

PA Neale, BI Escher, ML de Baat… - Environmental …, 2023 - ACS Publications
Effect-based methods (EBM) have great potential for water quality monitoring as they can
detect the mixture effects of all active known and unknown chemicals in a sample, which …