Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39

K Devantier, VMS Kjær, S Griffin… - British Journal of …, 2024 - Wiley Online Library
Viroporins possess important potential as antiviral targets due to their critical roles during
virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine …

Put a cork in it: Plugging the M2 viral ion channel to sink influenza

PH Jalily, MC Duncan, D Fedida, J Wang, I Tietjen - Antiviral research, 2020 - Elsevier
The ongoing threat of seasonal and pandemic influenza to human health requires antivirals
that can effectively supplement existing vaccination strategies. The M2 protein of influenza A …

SARS-CoV-2 E protein is a potential ion channel that can be inhibited by Gliclazide and Memantine

PPS Tomar, IT Arkin - Biochemical and Biophysical Research …, 2020 - Elsevier
COVID-19 is one of the most impactful pandemics in recorded history. As such, the
identification of inhibitory drugs against its etiological agent, SARS-CoV-2, is of utmost …

Blockers of the SARS-CoV-2 3a channel identified by targeted drug repurposing

PPS Tomar, M Krugliak, IT Arkin - Viruses, 2021 - mdpi.com
The etiological agent of the COVID-19 pandemic is SARS-CoV-2. As a member of the
Coronaviridae, the enveloped pathogen has several membrane proteins, of which two, E …

Zika M—A Potential Viroporin: Mutational Study and Drug Repurposing

PPS Tomar, M Krugliak, A Singh, IT Arkin - Biomedicines, 2022 - mdpi.com
Genus Flavivirus contains several important human pathogens. Among these, the Zika virus
is an emerging etiological agent that merits concern. One of its structural proteins, prM, plays …

Potential viroporin candidates from pathogenic viruses using bacteria-based bioassays

PPS Tomar, R Oren, M Krugliak, IT Arkin - Viruses, 2019 - mdpi.com
Viroporins are a family of small hydrophobic proteins found in many enveloped viruses that
are capable of ion transport. Building upon the ability to inhibit influenza by blocking its …

Identification of sars-cov-2 e channel blockers from a repurposed drug library

PPS Tomar, M Krugliak, IT Arkin - Pharmaceuticals, 2021 - mdpi.com
SARS-CoV-2, the etiological agent of the COVID-19 pandemic, is a member of the
Coronaviridae family. It is an enveloped virus with ion channels in its membrane, the most …

Amantadine resistance markers among low pathogenic avian influenza H9N2 viruses isolated from poultry in India, during 2009–2017

SS Kode, SD Pawar, DS Tare, SS Keng, J Mullick - Microbial pathogenesis, 2019 - Elsevier
Antiviral susceptibility screening of avian influenza (AI) H9N2 viruses is crucial considering
their role at the animal-human interface and potential to cause human infections. The Matrix …

Viroporins of Mpox Virus

K Basu, M Krugliak, IT Arkin - International Journal of Molecular Sciences, 2023 - mdpi.com
Mpox or monkeypox virus (MPXV) belongs to the subclass of Poxviridae and has emerged
recently as a global threat. With a limited number of anti-viral drugs available for this new …

Searching for blockers of dengue and West Nile virus Viroporins

H Lahiri, IT Arkin - Viruses, 2022 - mdpi.com
Flavivirus infections, such as those caused by dengue and West Nile viruses, emerge as
new challenges for the global healthcare sector. It has been found that these two viruses …