Despite marked improvements in the survival of patients with severe lupus nephritis over the
past 50 years, the rate of complete clinical remission after immune suppression therapy is< …

Recent advances in our understanding of the molecular pathways that control the link of
inflammation with organ fibrosis and autoimmune diseases point to the epithelial to …

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak
has caused devastating mortality and posed a great threat to public health. However, efforts …

Objectives: We investigated proinflammatory M1 and immunomodulatory M2 activation
profiles of circulating monocytes in relapsing experimental autoimmune encephalomyelitis …

Perinatal depression is one of the leading causes of maternal morbidity and mortality. The
biological etiology of this disorder remains in question, despite considerable research into …

SLE is an autoimmune inflammatory disease in which various pro‐and anti‐inflammatory
cytokines, including TGF‐β, IL‐10, BAFF, IL‐6, IFN‐α, IFN‐γ, IL‐17, and IL‐23, play crucial …

Transforming growth factor β (TGF-β) is a pleiotropic cytokine with vital homeostatic
functions. Aberrant TGF-β expression is implicated in the pathogenesis of fibrosis in …

Systemic lupus erythematosus (SLE) is a chronic systemic inflammatory autoimmune
disease characterized by a breakdown of tolerance to self. The autoantibodies generated in …

Lupus nephritis is a major cause of morbidity and mortality in patients with systemic lupus
erythematosus. The general consensus is that 60% of lupus patients will develop clinically …

MicroRNAs (miRs) seem to mediate renal fibrosis in several renal diseases, with some miRs
having profibrotic effects and others having opposing effects. Although differential …