p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is
dysregulated in some cancers. Earlier observations on p21 knockout models emphasized …

The p21-activated kinases (PAKs), downstream effectors of Ras-related Rho GTPase Cdc42
and Rac, are serine/threonine kinases. Biologically, PAKs participate in various cellular …

Abstract Pancreatic Ductal Adenocarcinoma (PDA) is one of the most lethal types of cancer
with a dismal prognosis. KRAS mutation is a commonly identified oncogene in PDA …

Osteoporosis is caused by disturbance in the dynamic balance of bone remodelling, a
physiological process, vital for maintenance of healthy bone tissue in adult humans. In this …

Cancer stem cells (CSCs) have unique properties, including self-renewal, differentiation,
and chemoresistance. In this study, we found that p21-activated kinase (PAK1) inhibitor …

Background Spermine is frequently elevated in tumor tissues and body fluids of cancer
patients and is critical for cancer cell proliferation, migration and invasion. However, the …

Tripartite motif-containing protein 26 (TRIM26) is a member of the TRIM protein family and
has been demonstrated to play crucial roles in several types of cancers. However, the …

Purpose: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors.
The malignant biological behavior of HCC is closely related to epithelial-mesenchymal …

To elucidate the potential function of miRNA-221 in gestational diabetes mellitus (GDM) and
the underlying mechanism. MiRNA-221 level was analyzed in the microarray containing …

Simple Summary Gastrointestinal tumors are the most common tumors with a high mortality
rate worldwide. Numerous protein kinases have been studied in anticipation of finding …