Insights on the mechanism of bleomycin to induce lung injury and associated in vivo models: a review

BL Ayilya, A Balde, M Ramya, S Benjakul… - International …, 2023 - Elsevier
Acute lung injury leads to the development of chronic conditions such as idiopathic
pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), asthma as well as …

Is there a role for specialized pro-resolving mediators in pulmonary fibrosis?

TH Thatcher, MAT Freeberg, YPA Myo… - Pharmacology & …, 2023 - Elsevier
Pulmonary fibrotic diseases are characterized by proliferation of lung fibroblasts and
myofibroblasts and excessive deposition of extracellular matrix proteins. Depending on the …

[HTML][HTML] Caffeic acid ethanolamide induces antifibrosis, anti-inflammatory, and antioxidant effects protects against bleomycin-induced pulmonary fibrosis

CW Huang, SY Lee, CX Du, ST Wu, YH Kuo… - Biomedicine & …, 2024 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease; its
cause is unknown, and it leads to notable health problems. Currently, only two drugs are …

[HTML][HTML] AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced lung remodelling

DC Villela, P Namsolleck, C Reichetzeder, GN Moll - Peptides, 2023 - Elsevier
This study aimed to evaluate the prophylactic and therapeutic potential of angiotensin II type
2 receptor peptide agonist LP2 in bleomycin-induced airway and cardiac remodeling in rats …

Functional Roles of CD26/DPP4 in Bleomycin-Induced Pulmonary Hypertension Associated with Interstitial Lung Disease

T Okaya, T Kawasaki, S Sato, Y Koyanagi… - International Journal of …, 2024 - mdpi.com
Pulmonary hypertension (PH) with interstitial lung diseases (ILDs) often causes intractable
conditions. CD26/Dipeptidyl peptidase-4 (DPP4) is expressed in lung constituent cells and …

Pharmacological Inhibition of Epac1 Protects against Pulmonary Fibrosis by Blocking FoxO3a Neddylation

K Jankowski, SE Lemay, D Lozano-Ojalvo… - bioRxiv, 2024 - biorxiv.org
Background. Idiopathic Pulmonary fibrosis (IPF) is characterized by progressive scarring
and fibrosis within the lungs. There is currently no cure for IPF; therefore, there is an urgent …

Rôle des canaux Orai et TRPC dans le développement de l'hypertension artérielle pulmonaire

B Masson - 2023 - theses.hal.science
L'hypertension artérielle pulmonaire (HTAP) est une maladie rare et sévère résultant d'un
intense remodelage de la paroi vasculaire conduisant à une obstruction progressive des …