An update on cognitive frailty: Its definition, impact, associated factors and underlying mechanisms, and interventions

T Sugimoto, H Arai, T Sakurai - Geriatrics & gerontology …, 2022 - Wiley Online Library
Since the concept and operational definition of “cognitive frailty”(simultaneous presence of
physical frailty and cognitive impairment without concurrent dementia) were proposed by the …

Cognitive frailty: an update

D Facal, C Burgo, C Spuch, P Gaspar… - Frontiers in …, 2021 - frontiersin.org
This review article provides an update of the empirical research on cognitive fragility
conducted in the last four years. The studies retrieved were classified in four different …

Frailty is associated with postoperative delirium but not with postoperative cognitive decline in older noncardiac surgery patients

E Mahanna-Gabrielli, K Zhang, FE Sieber… - Anesthesia & …, 2020 - journals.lww.com
BACKGROUND: Postoperative cognitive dysfunction (POCD) and delirium are the most
common perioperative cognitive complications in older adults undergoing surgery. A recent …

Exercise interventions for older people with cognitive frailty—a scoping review

X Li, Y Zhang, Y Tian, Q Cheng, Y Gao, M Gao - BMC geriatrics, 2022 - Springer
Background As the global population ages, the issue of frailty in older people is gaining
international attention. As one of the major subtypes of frailty, cognitive frailty is a …

Cognitive Frailty and Aging: Clinical Characteristics, Pathophysiological Mechanisms, and Potential Prevention Strategies

SG Aguilar-Navarro, AJ Mimenza-Alvarado… - Archives of Medical …, 2025 - Elsevier
Frailty has been conceptualized not only as a physical disease, but also as a multidomain
entity that encompasses a multimorbid status, disability, cognitive impairment, psychosocial …

A systematic review and meta-analysis on cognitive frailty in community-dwelling older adults: risk and associated factors

IP Vatanabe, RV Pedroso, RHG Teles… - Aging & mental …, 2022 - Taylor & Francis
Objectives To identify which factors are associated with cognitive frailty (CF), as well as the
impact of CF on the incidence of dementia and mortality. Methods A systematic review with …

Neurophysiological and brain structural markers of cognitive frailty differ from Alzheimer's disease

E Kocagoncu, D Nesbitt, T Emery… - Journal of …, 2022 - Soc Neuroscience
With increasing life span and prevalence of dementia, it is important to understand the
mechanisms of cognitive aging. Here, we focus on a subgroup of the population we term …

Understanding exogenous factors and biological mechanisms for cognitive frailty: a multidisciplinary scoping review

C Holland, N Dravecz, L Owens, A Benedetto… - Ageing Research …, 2024 - Elsevier
Cognitive frailty (CF) is the conjunction of cognitive impairment without dementia and
physical frailty. While predictors of each element are well-researched, mechanisms of their …

Exploring the relationship between frailty and executive dysfunction: the role of frontal white matter hyperintensities

N Pozo, C Romero, M Andrade, PH Délano… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction Frailty is a geriatric syndrome frequently associated with executive dysfunction
and white matter hyperintensities (WMH). But the relation between executive dysfunction …

Brain structural alterations and clinical features of cognitive frailty in Japanese community-dwelling older adults: the Arao study (JPSC-AD)

K Yoshiura, R Fukuhara, T Ishikawa, N Tsunoda… - Scientific Reports, 2022 - nature.com
Cognitive frailty (CF) is a clinical condition defined by the presence of both mild cognitive
impairment (MCI) and physical frailty (PF). Elderly with CF are at greater risk of dementia …