A wide array of chronic inflammatory conditions predispose susceptible cells to neoplastic
transformation. In general, the longer the inflammation persists, the higher the risk of cancer …

Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical
presentations that can escalate to acute liver failure. The worldwide increase in the use of …

The Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs),
endowing epithelial cells with migratory and invasive properties during both embryonic …

Chronic liver injury, resulted from different etiologies (eg, virus infection, alcohol abuse,
nonalcoholic steatohepatitis (NASH) and cholestasis) can lead to liver fibrosis characterized …

Liver damage ranges from acute hepatitis to hepatocellular carcinoma, through apoptosis,
necrosis, inflammation, immune response, fibrosis, ischemia, altered gene expression and …

Drug-induced nephrotoxicity contributes to acute kidney injury (AKI) and represents a major
problem in the clinical setting. We investigated the possible involvement of NLRP3 …

Dietary polyphenols have been associated with the reduced risk of chronic diseases such as
cancer, but the precise underlying mechanism of protection remains unclear. The aim of this …

Primary hepatocytes and their cultures are a simple but versatile, well-controlled, and
relatively easy to handle in vitro system that is well-accepted for investigating xenobiotic …

Olive leaf extract (OLE) has potential health benefits and protects against cytotoxicity in
different organs. However, nothing has yet been reported on its potential to prevent …

Significance: Hepatic fibrosis is the common pathophysiologic process resulting from
chronic liver injury, characterized by the accumulation of an excessive extracellular matrix …